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Type: Artigo de periódico
Title: Antiadhesive and Antibacterial Multilayer Films via Layer-by-Layer Assembly of TMC/Heparin Complexes
Author: Follmann, HDM
Martins, AF
Gerola, AP
Burgo, TAL
Nakamura, CV
Rubira, AF
Muniz, EC
Abstract: N-Trimethyl chitosan (TMC), an antibacterial agent, and heparin (HP), an antiadhesive biopolymer, were alternately deposited on modified polystyrene films, as substrates,, to built antiadhesive and antibacterial multilayer films. The properties of the multilayer films were investigated by Fourier transform infrared spectroscopy, atomic force Microscopy, scanning electron microscopy, and Kelvin force microscopy. In vitro studies of controlled. release of HP were evaluated in simulated intestinal fluid and simulated gastric fluid. The initial adhesion test of E. coli on multilayer films surface showed effective antiadhesive properties. The in vitro antibacterial test indicated that the multilayer films of TMC/HP based on TMC80 can kill the E. cob bacteria. Therefore, antiadhesive and antibacterial multilayer films may have good potential for coatings and Surface modification of biomedical applications.
Country: EUA
Editor: Amer Chemical Soc
Citation: Biomacromolecules. Amer Chemical Soc, v. 13, n. 11, n. 3711, n. 3722, 2012.
Rights: fechado
Identifier DOI: 10.1021/bm3011962
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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