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Type: Artigo de periódico
Title: Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni
Author: Verjovski-Almeida, S
DeMarco, R
Martins, EAL
Guimaraes, PEM
Ojopi, EPB
Paquola, ACM
Piazza, JP
Nishiyama, MY
Kitajima, JP
Adamson, RE
Ashton, PD
Bonaldo, MF
Coulson, PS
Dillon, GP
Farias, LP
Gregorio, SP
Ho, PL
Leite, RA
Malaquias, LCC
Marques, RCP
Miyasato, PA
Nascimento, ALTO
Ohlweiler, FP
Reis, EM
Ribeiro, MA
Sa, RG
Stukart, GC
Soares, MB
Gargioni, C
Kawano, T
Rodrigues, V
Madeira, AMBN
Wilson, RA
Menck, CFM
Setubal, JC
Leite, LCC
Dias-Neto, E
Abstract: Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags ( ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampling of an estimated 14,000 gene complement. By analyzing automated Gene Ontology assignments, we provide a detailed view of important S. mansoni biological systems, including characterization of metazoa-specific and eukarya-conserved genes. Phylogenetic analysis suggests an early divergence from other metazoa. The data set provides insights into the molecular mechanisms of tissue organization, development, signaling, sexual dimorphism, host interactions and immune evasion and identifies novel proteins to be investigated as vaccine candidates and potential drug targets.
Country: EUA
Editor: Nature Publishing Group
Citation: Nature Genetics. Nature Publishing Group, v. 35, n. 2, n. 148, n. 157, 2003.
Rights: fechado
Identifier DOI: 10.1038/ng1237
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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