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Type: Artigo de periódico
Title: Tumor Growth Characteristics of the Walker 256 AR Tumor, a Regressive Variant of the Rat Walker 256 A tumor
Author: Guimaraes, F
Schanoski, AS
Cavalcanti, TCS
Juliano, PB
Viera-Matos, AN
Rettori, O
Abstract: The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.
Subject: Tumor growth rate
spontaneous tumor regression
Wistar rats
Walker 256
Country: Brasil
Editor: Inst Tecnologia Parana
Citation: Brazilian Archives Of Biology And Technology. Inst Tecnologia Parana, v. 53, n. 5, n. 1101, n. 1108, 2010.
Rights: aberto
Identifier DOI: 10.1590/S1516-89132010000500014
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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