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Type: Artigo de periódico
Title: Adiponectin is related to intramyocellular lipid content in non-diabetic adults
Author: Godoy-Matos, AF
Bahia, LR
Domingues, RC
Sicuro, F
Tambascia, M
Geloneze, B
Kraemer-Aguiar, LG
Bouskela, E
Abstract: Objective: Insulin resistance (IR) is associated with intramyocellular lipid (IMCL) content and low serum adiponectin (ADP) levels and ADP is also involved in muscle fat oxidation. However, the relationship between ADP and IMCL content is still controversial and in this study we explored it further in non-diabetic adults. Design: Cross-sectional clinical study. Subjects: Thirty-three adult subjects, 24 obese non-diabetic patients with metabolic syndrome (MS) and 9 lean healthy controls. Measurements: Proton nuclear magnetic resonance spectroscopy ((1)H-NMRS) was performed to quantify IMCL content. The latter plus serum ADP, anthropometrics and biochemical parameters were evaluated and compared in these 2 groups. Results: MS patients had higher body mass index, waist, waist-to-hip ratio, glucose, insulin, and triglycerides and lower HDL cholesterol (HDL(c)) compared to controls. Homeostasis model assessment of IR (HOMA-IR) [3.25 (2.58-4.13) vs 1.02 (0.73-1.29); p<0.0001] and IMCL content [266.1 (189.9-296.3) vs 72.85 (55.3-109.4) AU, p<0.0001] were higher, and quantitative insulin-sensitivity check index (QUICK!) [0.32 (0.31-0.33) vs 0.38 (0.37-0.40); p<0.0001] and ADP [8.6 (4.05-15.95) vs 21.1 (12.9-24.4) mu g/ml; p=0.02] were lower in MS subjects compared to controls. IMCL content was directly associated to glucose, insulin, triglycerides, and HOMA-IR and inversely to HDLc, QUICK! and, more importantly, to ADP (r=-0.41; p<0.05). Only in the MS group, ADP partially influenced IMCL content. Conclusion: ADP is inversely related to IMCL content in non-diabetic adults. This finding has possible implications for the role of ADP in muscle fat oxidation, IR, and MS. (J. Endocrinol. Invest. 33: 382-387, 2010) (C)2010, Editrice Kurtis
Subject: Adiponectin
insulin resistance
intramyocellular lipid content
metabolic syndrome
Country: Itália
Editor: Editrice Kurtis S R L
Citation: Journal Of Endocrinological Investigation. Editrice Kurtis S R L, v. 33, n. 6, n. 382, n. 387, 2010.
Rights: fechado
Identifier DOI: 10.3275/6474
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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