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Type: Artigo de periódico
Title: A novel method for subarachnoid drug delivery in the medullary region of rats
Author: Fischer, L
Parada, CA
Tambeli, CH
Abstract: This study describes a novel method for direct subarachnoid drug delivery to the medullary dorsal horn region of rats, without introducing a catheter. The reliability of the method was demonstrated by a pharmacological validation; that is, morphine administration to the medullary region blocked the nociceptive response to formalin injected in the temporomandibular joint (TMJ) region, an effect that was prevented by co-administration of naloxone. The method proposed offers many advantages over the existing methods for medullary drug delivery with catheter implantation. It is easy to be employed, it does not induce any sign of motor impairment, and it does not require the neck surgery performed to implant a catheter in the medullary dorsal horn region. Therefore, it is a useful method for subarachnoid drug delivery in behavioral trigeminal pain studies, particularly when nociceptive behavioral measures that require normal neck muscle activity to occur, such as head withdraw or head flinch are evaluated. (c) 2005 Elsevier B.V. All rights reserved.
Subject: subarachnoid drug delivery
nociceptive behavior
medullary dorsal horn
Country: Holanda
Editor: Elsevier Science Bv
Citation: Journal Of Neuroscience Methods. Elsevier Science Bv, v. 148, n. 2, n. 108, n. 112, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.jneumeth.2005.04.021
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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