Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/76261
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleWalker 256 tumor MHC class I expression during the shift from A variant to the immunogenic AR variantpt_BR
dc.contributor.authorSchanoski, ASpt_BR
dc.contributor.authorCavalcanti, TCpt_BR
dc.contributor.authorBarbosa, Cpt_BR
dc.contributor.authorCampos, Lpt_BR
dc.contributor.authorViera-Matos, ANpt_BR
dc.contributor.authorRettori, Opt_BR
dc.contributor.authorGuimaraes, Fpt_BR
unicamp.author.emailsamico@caism.unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Lab Pesquisas Bioquim, Ctr Assistencia Integral Saude Mulher, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Lab Bioenerget, Dept Patol Clin, Fac Ciencias Med, BR-13083970 Campinas, SP, Brazil Univ Estadual Santa Cruz, Dept Ciencia Saude, Coll Med, Ilheus, BA, Brazilpt_BR
dc.subjectAMC class I expressionpt_BR
dc.subjectascitic tumorpt_BR
dc.subjecttumor cell variantspt_BR
dc.subjectWalker 256 tumorpt_BR
dc.subject.wosNk Cellspt_BR
dc.subject.wosRatspt_BR
dc.subject.wosAntigenspt_BR
dc.subject.wosEscapept_BR
dc.subject.wosFibrosarcomapt_BR
dc.subject.wosLymphocytespt_BR
dc.subject.wosGrowthpt_BR
dc.subject.wosAnemiapt_BR
dc.subject.wosMicept_BR
dc.description.abstractNovel tumor cell variants can be obtained by serially passaging tumor cells in different media and/or environments. Serial intraperitoneal (ip) passages of the Walker 256 tumor A variant was followed for studying the generation of its regressive AR variant. MHC class I molecule expression was assessed since variations in this molecule would explain changes in tumor cell immunogenicity and therefore, the shift from progressive A variant to the regressive AR variant. Within 25 ip passages all serial repetitions shifted from A to AR variant, which was characterized by a significant increase in red blood cell (R13Q osmotic fragility with marked spleen hypertrophy in the host. In one serial repetition AR tumor cells were rejected tip passage number 36) and immunity against the AR and A variants was conferred. Flow cytometry analysis showed a significant increase in the number MHC class I positive cells in AR variant (n = 15, 14.21 +/- 1.32) compared with A variant (n = 10, 9.10 +/- 1.22). These data provide evidence that the generation of the AR variant could result from factors present in the ip environment leading to an increase in the number of Walker 256 MHC class I positive tumor cells, probably due to immune selection of MHC class I negative tumor cells. (C) 2004 Published by Elsevier Ireland Ltd.pt
dc.relation.ispartofCancer Letterspt_BR
dc.relation.ispartofabbreviationCancer Lett.pt_BR
dc.publisher.cityClarept_BR
dc.publisher.countryIrlandapt_BR
dc.publisherElsevier Sci Ireland Ltdpt_BR
dc.date.issued2004pt_BR
dc.date.monthofcirculation46935pt_BR
dc.identifier.citationCancer Letters. Elsevier Sci Ireland Ltd, v. 211, n. 1, n. 119, n. 127, 2004.pt_BR
dc.language.isoenpt_BR
dc.description.volume211pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage119pt_BR
dc.description.lastpage127pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0304-3835pt_BR
dc.identifier.wosidWOS:000222476100014pt_BR
dc.identifier.doi10.1016/j.canlet.2004.01.023pt_BR
dc.date.available2014-11-13T23:54:50Z
dc.date.available2015-11-26T16:03:20Z-
dc.date.accessioned2014-11-13T23:54:50Z
dc.date.accessioned2015-11-26T16:03:20Z-
dc.description.provenanceMade available in DSpace on 2014-11-13T23:54:50Z (GMT). No. of bitstreams: 1 WOS000222476100014.pdf: 272533 bytes, checksum: 5e50043e77837e1f9fd85f9ead019368 (MD5) Previous issue date: 2004en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:03:20Z (GMT). No. of bitstreams: 2 WOS000222476100014.pdf: 272533 bytes, checksum: 5e50043e77837e1f9fd85f9ead019368 (MD5) WOS000222476100014.pdf.txt: 28810 bytes, checksum: 67250411328549cc4295964959d1f015 (MD5) Previous issue date: 2004en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76261pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/76261
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76261-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000222476100014.pdf266.15 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.