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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleVolumetric Brain Changes in Thalamus, Corpus Callosum and Medial Temporal Structures: Mild Alzheimer's Disease Compared with Amnestic Mild Cognitive Impairmentpt_BR
dc.contributor.authorPedro, Tpt_BR
dc.contributor.authorWeiler, Mpt_BR
dc.contributor.authorYasuda, CLpt_BR
dc.contributor.authorD'Abreu, Apt_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorCendes, Fpt_BR
dc.contributor.authorBalthazar, MLFpt_BR
unicamp.author.emailmbalth@unicamp.brpt_BR
unicamp.authorPedro, Tatiane Weiler, Marina Yasuda, Clarissa L. D'Abreu, Anelyssa Cendes, Fernando Balthazar, Marcio L. F. Univ Estadual Campinas, UNICAMP, Dept Neurol, Neuroimaging Lab,FCM, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorDamasceno, Benito P. Balthazar, Marcio L. F. Univ Estadual Campinas, UNICAMP, Dept Neurol, Unit Neuropsychol & Neurolinguist,FCM, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectAlzheimer's diseasept_BR
dc.subjectAmnestic mild cognitive impairmentpt_BR
dc.subjectThalamuspt_BR
dc.subjectCorpus callosumpt_BR
dc.subjectVolumetrypt_BR
dc.subject.wosVoxel-based Morphometrypt_BR
dc.subject.wosGray-matter Losspt_BR
dc.subject.wosEntorhinal Cortexpt_BR
dc.subject.wosDementiapt_BR
dc.subject.wosAtrophypt_BR
dc.subject.wosMript_BR
dc.subject.wosHippocampuspt_BR
dc.subject.wosDeclinept_BR
dc.subject.wosDegenerationpt_BR
dc.subject.wosPatternpt_BR
dc.description.abstractBackground: It is widely known that atrophy of medial temporal structures is present in the mild stage of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, structures such as the thalamus and corpus callosum are much less studied. Methods: We compared the volumes of the entorhinal cortex, hippocampus, thalamus and the corpus callosum in 14 controls, 14 patients with mild AD and 15 with aMCI and correlated these volumes with neuropsychological data. MRI was obtained at 2 T followed by manual segmentation. Results: We found atrophy in hippocampi and thalami of MCI patients compared to controls, and in the bilateral entorhinal cortex of aMCI compared to AD patients. All the structures showed atrophy in AD patients compared to controls, including the corpus callosum. Conclusions: Our study confirms that thalamic areas are atrophied in aMCI, and the corpus callosum might represent a good structural marker for mild AD. Those areas were associated with cognitive functions already described in the literature. Copyright (C) 2012 S. Karger AG, Baselpt
dc.relation.ispartofDementia And Geriatric Cognitive Disorderspt_BR
dc.relation.ispartofabbreviationDement. Geriatr. Cogn. Disord.pt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherKargerpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationDementia And Geriatric Cognitive Disorders. Karger, v. 34, n. 41732, n. 149, n. 155, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume34pt_BR
dc.description.issuenumber41732pt_BR
dc.description.firstpage149pt_BR
dc.description.lastpage155pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.karger.com/Services/RightsPermissionspt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1420-8008pt_BR
dc.identifier.wosidWOS:000312897800002pt_BR
dc.identifier.doi10.1159/000342118pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2009/02179-2]pt
dc.date.available2014-08-01T18:15:59Z
dc.date.available2015-11-26T16:59:32Z-
dc.date.accessioned2014-08-01T18:15:59Z
dc.date.accessioned2015-11-26T16:59:32Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:15:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:59:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76230
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76230-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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