Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/76112
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA multimodal evaluation of microstructural white matter damage in spinocerebellar ataxia type 3pt_BR
dc.contributor.authorGuimaraes, RPpt_BR
dc.contributor.authorD'Abreu, Apt_BR
dc.contributor.authorYasuda, CLpt_BR
dc.contributor.authorFranca, MCpt_BR
dc.contributor.authorSilva, BHBpt_BR
dc.contributor.authorCappabianco, FAMpt_BR
dc.contributor.authorBergo, FPGpt_BR
dc.contributor.authorLopes-Cendes, ITpt_BR
dc.contributor.authorCendes, Fpt_BR
unicamp.author.emailfcendes@unicamp.brpt_BR
unicamp.authorGuimaraes, Rachel P. D'Abreu, Anelyssa Yasuda, Clarissa L. Franca, Marcondes C., Jr. Silva, Beatriz H. B. Bergo, Felipe P. G. Cendes, Fernando Univ Campinas UNICAMP, Dept Neurol, Fac Med, Sao Paulo, Brazilpt_BR
unicamp.authorGuimaraes, Rachel P. D'Abreu, Anelyssa Yasuda, Clarissa L. Franca, Marcondes C., Jr. Silva, Beatriz H. B. Bergo, Felipe P. G. Cendes, Fernando Univ Campinas UNICAMP, Neuroimaging Lab, Fac Med, Sao Paulo, Brazilpt_BR
unicamp.authorCappabianco, Fabio A. M. Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Paulo, Brazilpt_BR
unicamp.authorLopes-Cendes, Iscia T. Univ Campinas UNICAMP, Fac Med, Dept Med Genet, Sao Paulo, Brazilpt_BR
dc.subjectMachado-Joseph diseasept_BR
dc.subjectMRIpt_BR
dc.subjectDTIpt_BR
dc.subjectVBMpt_BR
dc.subject.wosMachado-joseph-diseasept_BR
dc.subject.wosFractional Anisotropypt_BR
dc.subject.wosParkinsons-diseasept_BR
dc.subject.wosClinical-featurespt_BR
dc.subject.wosBrain-stempt_BR
dc.subject.wosDiffusivitypt_BR
dc.subject.wosReliabilitypt_BR
dc.subject.wosCerebellumpt_BR
dc.subject.wosValiditypt_BR
dc.subject.wosAtrophypt_BR
dc.description.abstractAlthough white matter damage may play a major role in the pathogenesis of spinocerebellar ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. In this setting we designed a study to investigate white matter integrity. We evaluated 38 genetically-confirmed SCA3 patients (mean age, 52.76 +/- 12.70 years; 21 males) with clinical scales and brain magnetic resonance imaging (MRI) and 38 healthy subjects as a control group (mean age, 48.86 +/- 12.07 years, 20 male). All individuals underwent the same protocol for high-resolution T1 and T2 images and diffusion tensor imaging acquisition (32 directions) in a 3-T scanner. We used Tract-Based Spatial Statistics (FSL 4.1.4) to analyze diffusion data and SPM8/DARTEL for voxel-based morphometry of infratentorial structures. T2-relaxometry of cerebellum was performed with in-house-developed software Aftervoxel and Interactive Volume Segmentation (IVS). Patients' mean age at onset was 40.02 +/- 11.48 years and mean duration of disease was 9.3 +/- 2.7 years. Mean International Cooperative Ataxia Rating Scale (ICARS) and Scale for Assessment and Rating of Ataxia (SARA) scores were 32.08 +/- 4.01 and 14.65 +/- 7.33, respectively. Voxel-based morphometry demonstrated a volumetric reduction of gray and white matter in cerebellum and brainstem (P <.001). We found reduced fractional anisotropy (P <.05) in the cerebellum and brainstem. There were also areas of increased radial diffusivity (P <.05) in the cerebellum, brainstem, thalamus, frontal lobes, and temporal lobes. In addition, we found decreased T2-relaxation values in the white matter of the right cerebellar hemisphere. Microstructural white matter dysfunction, not previously reported, occurs in the cerebellum and brainstem of SCA3 patients. (c) 2013 Movement Disorder Societypt
dc.relation.ispartofMovement Disorderspt_BR
dc.relation.ispartofabbreviationMov. Disord.pt_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationMovement Disorders. Wiley-blackwell, v. 28, n. 8, n. 1125, n. 1132, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume28pt_BR
dc.description.issuenumber8pt_BR
dc.description.firstpage1125pt_BR
dc.description.lastpage1132pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0885-3185pt_BR
dc.identifier.wosidWOS:000322960800023pt_BR
dc.identifier.doi10.1002/mds.25451pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-08-01T18:15:35Z
dc.date.available2015-11-26T16:58:36Z-
dc.date.accessioned2014-08-01T18:15:35Z
dc.date.accessioned2015-11-26T16:58:36Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:15:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:58:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76112
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76112-
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