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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA low-protein diet during pregnancy alters glucose metabolism and insulin secretionpt_BR
dc.contributor.authorSouza, DDIpt_BR
dc.contributor.authorIgnacio-Souza, LMpt_BR
dc.contributor.authorReis, SRDpt_BR
dc.contributor.authorReis, MADpt_BR
dc.contributor.authorStoppiglia, LFpt_BR
dc.contributor.authorCarneiro, EMpt_BR
dc.contributor.authorBoschero, ACpt_BR
dc.contributor.authorArantes, VCpt_BR
dc.contributor.authorLatorraca, MQpt_BR
unicamp.authorIgnacio-Souza, Leticia M. Reis, Silvia Regina de L. Stoppiglia, Luiz Fabrizio Arantes, Vanessa Cristina Latorraca, Marcia Queiroz Univ Fed Mato Grosso, Fac Nutr, Dept Alimentos & Nutr, BR-78060900 Cuiaba, MT, Brazilpt_BR
unicamp.authorSouza, Denise de Fatima I. UNIMED, Cuiaba, MT, Brazilpt_BR
unicamp.authorReis, Marise Auxiliadora de B. Univ Fed Mato Grosso, Fac Ciencias Med, Dept Ciencias Basicas Saude, BR-78060900 Cuiaba, MT, Brazilpt_BR
unicamp.authorCarneiro, Everardo Magalhaes Boschero, Antonio Carlos Univ Estadual Campinas, Inst Biol, Dept Anat Biol Celular & Fisiol, Campinas, SP, Brazilpt_BR
dc.subjectlow-protein dietpt_BR
dc.subjectglucose metabolismpt_BR
dc.subjectpancreatic isletspt_BR
dc.subjectinsulin secretionpt_BR
dc.subject.wosRat Isletspt_BR
dc.description.abstractIn pancreatic islets, glucose metabolism is a key process for insulin secretion, and pregnancy requires an increase in insulin secretion to compensate for the typical insulin resistance at the end of this period. Because a low-protein diet decreases insulin secretion, this type of diet could impair glucose homeostasis, leading to gestational diabetes. In pancreatic islets, we investigated GLUT2, glucokinase and hexokinase expression patterns as well as glucose uptake, utilization and oxidation rates. Adult control non-pregnant (CNP) and control pregnant (CP) rats were fed a normal protein diet (17%), whereas low-protein non-pregnant (LPNP) and low-protein pregnant (LPP) rats were fed a low-protein diet (6%) from days 1 to 15 of pregnancy. The insulin secretion in 2.8?mmol l-1 of glucose was higher in islets from LPP rats than that in islets from CP, CNP and LPNP rats. Maximal insulin release was obtained at 8.3 and 16.7?mmol l-1 of glucose in LPP and CP groups, respectively. The glucose doseresponse curve from LPNP group was shifted to the right in relation to the CNP group. In the CP group, the concentrationresponse curve to glucose was shifted to the left compared with the CNP group. The LPP groups exhibited an inverted U-shape doseresponse curve. The alterations in the GLUT2, glucokinase and hexokinase expression patterns neither impaired glucose metabolism nor correlated with glucose islet sensitivity, suggesting that beta-cell sensitivity to glucose requires secondary events other than the observed metabolic/molecular events. Copyright (c) 2011 John Wiley & Sons,
dc.relation.ispartofCell Biochemistry And Functionpt_BR
dc.relation.ispartofabbreviationCell Biochem. Funct.pt_BR
dc.identifier.citationCell Biochemistry And Function. Wiley-blackwell, v. 30, n. 2, n. 114, n. 121, 2012.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Mato Grosso [0786/2006]pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFundacao de Amparo a Pesquisa do Estado de Mato Grosso [0786/2006]pt
dc.description.sponsordocumentnumberCNPq [305155/2004-0]pt
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