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Type: Artigo de periódico
Title: Sex hormone binding globulin and free levonorgestrel index in the first week after insertion of Norplant((R)) implants
Author: Alvarez, F
Brache, V
Tejada, AS
Cochon, L
Faundes, A
Abstract: Levonorgestrel has nn inhibitory effect on sex hormone binding globulin (SHBG). This decrease in SHBG lends to an increase in the free levonorgestrel index (FLI), which has a stronger biological effect. The interaction between serum levels of levonorgestrel and SHBG in long-term users of Norplant(R) implants has been described. This study was designed to understand the same interaction immediately after the insertion of the implants, in a group of 16 women, sampled at 0 and 6 h and at 1, 3, and 7 days after Norplant implant insertion. Peak serum levonorgestrel levels were achieved at 24 h after insertion, remaining stable on day 3 and decreasing by >10% by day 7. SHBG did not change during the first 24 h, but decreased by 19% and 60% on days 3 and 7, respectively. FLI more than doubled from day 1 to day 7 after insertion. The large decrease in SHBG and doubling of FLI is not followed by a similar reduction in levonorgestrel, which is hard to explain without an increase in the release rate of the steroid from the capsule. (C) 1998 Elsevier Science Inc. All rights reserved.
Subject: Norplant((R)) implant
levonorgestrel serum level
sex hormone binding globulin
Country: EUA
Editor: Elsevier Science Inc
Citation: Contraception. Elsevier Science Inc, v. 58, n. 4, n. 211, n. 214, 1998.
Rights: fechado
Identifier DOI: 10.1016/S0010-7824(98)00102-4
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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