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Type: Artigo de periódico
Title: Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation
Author: Visentainer, JEL
Lieber, SR
Persoli, LBL
Vigorito, AC
Aranha, FJP
Eid, KAD
Oliveira, GB
Miranda, ECM
de Souza, CA
Abstract: Objective. The aim of this study was to investigate whether the serum levels of soluble interleukin-2R (sIL-2R), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), IL-6, IL-10, and transforming growth factor-beta(1) (TGF-beta(1)) were associated with the development of acute graft-vs-host disease (aGVHD). Patients and Methods. Serum cytokine levels were sequentially measured by sandwich enzyme-linked immunosorbent assay in 13 patients who had received full-match allogeneic hematopoietic stem cell transplantation (HSCT). Results. Serum sIL-2R and IL-10 levels from the 1st to the 15th week post transplantation were significantly higher in the group that developed aGVHD than in the group without aGVHD. sIL-2R levels increased in direct correlation to engraftment and at onset of aGVHD, whereas IL-10 levels increased transiently following HSCT. The mean TNF-alpha concentration in the first weeks after transplantation was augmented in the group that developed aGVHD. Furthermore, a decrease in TGF-beta(1), levels after engraftment was significantly associated with aGVHD. No correlation was found between aGVHD and the other cytokines. Conclusions. These results support the idea that a balance between cytokines derived from type I and type 2 T-helper cells may be important in the development and control of aGVHD. Although sIL-2R, TNF-alpha, IL-10, and TGF-beta(1) levels have been correlated with aGVHD, sIL-2R levels at engraftment may provide a better parameter for early detection of aGVHD after allogeneic HSCT. (C) 2003 International Society for Experimental Hematology. Published by Elsevier Inc.
Country: EUA
Editor: Elsevier Science Inc
Citation: Experimental Hematology. Elsevier Science Inc, v. 31, n. 11, n. 1044, n. 1050, 2003.
Rights: fechado
Identifier DOI: 10.1016/j.exphem.2003.08.005
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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