Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/74375
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSpinal Cord Atrophy Correlates with Disability in Friedreich's Ataxiapt_BR
dc.contributor.authorChevis, CFpt_BR
dc.contributor.authorda Silva, CBpt_BR
dc.contributor.authorD'Abreu, Apt_BR
dc.contributor.authorLopes-Cendes, Ipt_BR
dc.contributor.authorCendes, Fpt_BR
dc.contributor.authorBergo, FPGpt_BR
dc.contributor.authorFranca, MCpt_BR
unicamp.author.emailmcfrancajr@uol.com.brpt_BR
unicamp.authorChevis, Camila F. da Silva, Cynthia B. D'Abreu, Anelyssa Lopes-Cendes, Iscia Bergo, Felipe P. G. Franca, Marcondes C., Jr. Univ Campinas UNICAMP, Dept Neurol & Neuroimaging Lab, Fac Med, BR-13083887 Sao Paulo, Brazilpt_BR
unicamp.authorLopes-Cendes, Iscia Univ Campinas UNICAMP, Fac Med, Dept Med Genet, BR-13083887 Sao Paulo, Brazilpt_BR
dc.subjectFriedreich's ataxiapt_BR
dc.subjectSpinal cordpt_BR
dc.subjectMRIpt_BR
dc.subjectAtrophypt_BR
dc.subject.wosRetained Tendon Reflexespt_BR
dc.subject.wosOnset Cerebellar-ataxiapt_BR
dc.subject.wosDiseasept_BR
dc.subject.wosBrainpt_BR
dc.subject.wosMript_BR
dc.subject.wosPathogenesispt_BR
dc.subject.wosPathologypt_BR
dc.subject.wosType-3pt_BR
dc.description.abstractAlthough Friedreich's ataxia is characterized by spinal cord atrophy, it remains to be investigated the possible correlation of such atrophy with clinical disability and genetic parameters. Thirty-three patients with Friedreich's ataxia and 30 healthy controls underwent MRI on a 3 T scanner. We used T1-weighted 3D images to estimate spinal cord area and eccentricity at C2/C3 level based on a semi-automatic image segmentation protocol. We quantified severity of ataxia with the Friedreich ataxia rating scale (FARS). Mean cord area in Friedreich's ataxia was smaller than in controls (38 vs 67.9 mm(2), p < 0.001). In contrast, mean cord eccentricity was significantly higher in Friedreich's ataxia when compared to the controls (0.82 vs 0.76, p < 0.001). There was a significant correlation between cord areas and the FARS scores (r = -0.53, p = 0.002). Cord damage in Friedreich's ataxia results in atrophy combined with flattening. Cord area is associated to clinical disability and might be useful as a biomarker in the disease.pt
dc.relation.ispartofCerebellumpt_BR
dc.relation.ispartofabbreviationCerebellumpt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherSpringerpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationFEBpt_BR
dc.identifier.citationCerebellum. Springer, v. 12, n. 1, n. 43, n. 47, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume12pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage43pt_BR
dc.description.lastpage47pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1473-4222pt_BR
dc.identifier.wosidWOS:000313203500005pt_BR
dc.identifier.doi10.1007/s12311-012-0390-6pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-07-30T20:02:22Z
dc.date.available2015-11-26T16:57:14Z-
dc.date.accessioned2014-07-30T20:02:22Z
dc.date.accessioned2015-11-26T16:57:14Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T20:02:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:57:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74375
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74375-
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