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Type: Artigo de periódico
Title: Simultaneous determination of first-line anti-tuberculosis drugs by capillary zone electrophoresis using direct UV detection
Author: Faria, AF
de Souza, MVN
Bruns, RE
de Oliveira, MAL
Abstract: An alternative methodology for simultaneous analysis of ethambutol, isoniazid, rifampicin and pyrazinamide in pharmaceutical formulations by capillary zone electrophoresis under UV direct detection with an analysis time of 8.0 min is proposed. Background running was based on the effective mobility curve of the analytes and an optimum separation condition was achieved using a 3(3) Box-Behnken design, with Brij 35, Cu(2+) and acetic acid/sodium acetate buffer as factors. An electrolyte consisting of 50.0 mmol L(-1) of acetic acid/sodium acetate buffer:12.5 mmol L(-1) of CuSO(4), and standard and sample solutions prepared in 2.00 mmol L(-1) of Brij 35 and 12.5 mmol L(-1) of CuSO(4) were optimized. After evaluating validation parameters, the method was successfully applied to the analysis of samples in the form of tablets and sachets. (C) 2010 Elsevier By. All rights reserved.
Subject: Capillary zone electrophoresis
Pharmaceutical formulation
Country: Holanda
Editor: Elsevier Science Bv
Citation: Talanta. Elsevier Science Bv, v. 82, n. 1, n. 333, n. 339, 2010.
Rights: fechado
Identifier DOI: 10.1016/j.talanta.2010.04.044
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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