Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/74190
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSimultaneous analysis of first-line anti-tuberculosis drugs in tablets by UV spectrophotometry compared to capillary zone electrophoresispt_BR
dc.contributor.authorMarcellos, LFpt_BR
dc.contributor.authorFaria, AFpt_BR
dc.contributor.authorde Souza, MVNpt_BR
dc.contributor.authorAlmeida, MRpt_BR
dc.contributor.authorSabin, GPpt_BR
dc.contributor.authorPoppi, RJpt_BR
dc.contributor.authorde Oliveira, MALpt_BR
unicamp.author.emailmarcone.oliveira@ufjf.edu.brpt_BR
unicamp.authorMarcellos, Luiza F. Faria, Adriana F. de Oliveira, Marcone A. L. Univ Fed Juiz de Fora, Dept Chem ICE, BR-36036330 Juiz De Fora, MG, Brazilpt_BR
unicamp.authorde Souza, Marcus V. N. Fundacao Oswaldo Cruz, Inst Technol Pharmaceut Farmanguinhos, BR-21041250 Rio De Janeiro, Brazilpt_BR
unicamp.authorAlmeida, Mariana R. Sabin, Guilherme P. Poppi, Ronei J. Univ Estadual Campinas, Inst Chem, BR-13084971 Campinas, SP, Brazilpt_BR
dc.subject4-FDCpt_BR
dc.subjectUV spectrophotometrypt_BR
dc.subjectChemometricspt_BR
dc.subjectCapillary electrophoresispt_BR
dc.subject.wosFixed-dose Combinationpt_BR
dc.subject.wosPharmaceutical Formulationspt_BR
dc.subject.wosPulmonary Tuberculosispt_BR
dc.subject.wosAnalytical-chemistrypt_BR
dc.subject.wosCalibrationpt_BR
dc.subject.wosRifampicinpt_BR
dc.subject.wosPyrazinamidept_BR
dc.subject.wosComplexationpt_BR
dc.subject.wosEthambutolpt_BR
dc.description.abstractThe development and optimization of a novel UV spectrophotometric methodology was proposed for simultaneous analysis of ethambutol (ETB), isoniazid (ISO), rifampicin (RIF) and pyrazinamide (PYR), using multivariate calibration based on the partial least squares method (PLS). The methodology was successfully applied for analysis of four-drug fixed dose combination (4-FDC) tablets used for tuberculosis treatment. A 3(4) Box-Behnken design, with triplicate in central point, was used for sample preparation in the calibration step. In the present case, nine latent variables were chosen for the model development that presented the smallest RMSECV and explain 98.76% of data variance in Y block (concentrations of ETB ISO, RIF and PYR) and 99.93% of data variance in X block (spectral data). PLS models for ETB, ISO, RIF and PYR presented RMSEP and R-2 values of 0.23 mg L-1 and 0.971; 0.14 mg L-1 and 0.731; 0.11 mg L-1 and 0.990 and 0.57 mg L-1 and 0.972, respectively. A validation step was performed based on the comparison between the UV spectrophotometric proposed methodology and capillary zone electrophoresis (CZE) in 4-FDC real samples and no significant difference was found between two methodologies at 95% of confidence level.pt
dc.relation.ispartofCentral European Journal Of Chemistrypt_BR
dc.relation.ispartofabbreviationCent. Eur. J. Chempt_BR
dc.publisher.cityWarsawpt_BR
dc.publisher.countryPolóniapt_BR
dc.publisherVersitapt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationDECpt_BR
dc.identifier.citationCentral European Journal Of Chemistry. Versita, v. 10, n. 6, n. 1808, n. 1816, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume10pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage1808pt_BR
dc.description.lastpage1816pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1895-1066pt_BR
dc.identifier.wosidWOS:000308950500009pt_BR
dc.identifier.doi10.2478/s11532-012-0102-6pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsordocumentnumberCNPq [CNPq - 300593/2008-2]pt
dc.description.sponsordocumentnumberFundacao de Amparo a Pesquisa do Estado de Minas Gerais of Brazil [FAPEMIG - CEX - APQ-02420-11, CEX - PPM-00205-11]pt
dc.date.available2014-07-30T19:57:47Z
dc.date.available2015-11-26T16:57:06Z-
dc.date.accessioned2014-07-30T19:57:47Z
dc.date.accessioned2015-11-26T16:57:06Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T19:57:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:57:06Z (GMT). No. of bitstreams: 2 WOS000308950500009.pdf: 989017 bytes, checksum: 2f2166996393a6ba3f0cc0b1444851e5 (MD5) WOS000308950500009.pdf.txt: 27240 bytes, checksum: 27caf4ffc5339b5931df8aedce3bd119 (MD5) Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74190
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74190-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000308950500009.pdf965.84 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.