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Type: Artigo de periódico
Title: Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity
Author: Pereira, RMS
Andrades, NED
Paulino, N
Sawaya, ACHF
Eberlin, MN
Marcucci, MC
Favero, GM
Novak, EM
Bydlowski, SP
Abstract: The antioxidant activity of flavonoids is believed to increase when they are coordinated with transition metal ions. However, the literature on this subject is contradictory and the outcome seems to largely depend on the experimental conditions. In order to understand the contribution of the metal coordination and the type of interaction between a flavonoid and the metal ion, in this study a new metal complex of Cu (II) with naringin was synthesized and characterized by FT-IR, UV-VIS, mass spectrometry (ESI-MS/MS), elemental analysis and H-1-NMR. The results of these analyses indicate that the complex has a Cu (II) ion coordinated via positions 4 and 5 of the flavonoid. The antioxidant, anti-inflammatory and antimicrobial activities of this complex were studied and compared with the activity of free naringin. The Naringin-Cu. (H) complex 1 showed higher antioxidant, anti-inflammatory and tumor cell cytoxicity activities than free naringin without reducing cell viability.
Subject: naringin complexes
antimicrobial and antioxidant activities
Country: Suíça
Editor: Molecular Diversity Preservation Int
Citation: Molecules. Molecular Diversity Preservation Int, v. 12, n. 7, n. 1352, n. 1366, 2007.
Rights: aberto
Identifier DOI: 10.3390/12071352
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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