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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleThe improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodilpt_BR
dc.contributor.authorRondon, ESpt_BR
dc.contributor.authorVieira, ASpt_BR
dc.contributor.authorValadao, CAApt_BR
dc.contributor.authorParada, CApt_BR
unicamp.author.emailitacron@gmail.compt_BR
unicamp.authorRondon, Eric Schmidt Univ Fed Mato Grosso, UFMS, Fac Vet Med & Anim Sci FAMEZ, Dept Vet Med, BR-79070460 Campo Grande, MS, Brazilpt_BR
unicamp.authorRondon, Eric Schmidt Araujo Valadao, Carlos Augusto UNESP Univ Estadual Paulista, Dept Vet Clin & Surg, Fac Agr & Vet Sci FCAV, BR-14884900 Sao Paulo, Brazilpt_BR
unicamp.authorVieira, Andre Schwambach Parada, Carlos Amilcar Univ Estadual Campinas, UNICAMP, Dept Physiol & Biophys, Inst Biol, BR-13083970 Sao Paulo, Brazilpt_BR
dc.subjectAnalgesiapt_BR
dc.subjectInflammatory painpt_BR
dc.subjectKetaminept_BR
dc.subjectIfenprodilpt_BR
dc.subject(Rat)pt_BR
dc.subject.wosD-aspartate Receptorpt_BR
dc.subject.wosNmda-receptorpt_BR
dc.subject.wosDorsal-hornpt_BR
dc.subject.wosIntravenous Ketaminept_BR
dc.subject.wosClinical-experiencept_BR
dc.subject.wosPrimary Afferentspt_BR
dc.subject.wosNeuropathic Painpt_BR
dc.subject.wosWind-uppt_BR
dc.subject.wosRatspt_BR
dc.subject.wosAntagonistpt_BR
dc.description.abstractIntrathecal or epidural administration of NMDA (N-methyl-D-aspartate) receptors antagonists, in special ketamine and ifenprodil are used to control moderate to severe hyperalgesia in humans. Activation of NMDA receptor usually requires binding of two agonists, glutamate and glycine, in different receptor subunits. Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor. The aim of this study was to investigate the pharmacological interactions between ketamine or its isomers and ifenprodil, when intrathecally co-administrated, to reduce prostaglandin E(2)-induced hyperalgesia in rat's hind paw. The intrathecal administration of ketamine, its isomers R(-) or S(+), or ifenprodil-induced anti-hyperalgesic effects in a dose-related manner. Ifenprodil, in a dose that did not induce significant effect when administrated alone, significantly improved the anti-hyperalgesic effect of ketamine or its isomers. The other way round, ketamine or S(+) ketamine, but not R(-) ketamine, in a dose that did not induce significant effect when administrated alone, improved the anti-hyperalgesic effect of ifenprodil. However, by comparing ED(50)s (half maximal effective doses), ifenprodil-induced potentiation of ketamine was significantly greater than ketamine-induced potentiation of ifenprodil. The findings of this present study suggest that intrathecal administration of very small doses of ifenprodil, just before and ketamine significantly improves its anti-hyperalgesic effect and this association could be useful to control inflammatory pain with less undesirable effects. (c) 2010 Elsevier B.V. All rights reserved.pt
dc.relation.ispartofEuropean Journal Of Pharmacologypt_BR
dc.relation.ispartofabbreviationEur. J. Pharmacol.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculation45962pt_BR
dc.identifier.citationEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 647, n. 41699, n. 84, n. 89, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume647pt_BR
dc.description.issuenumber41699pt_BR
dc.description.firstpage84pt_BR
dc.description.lastpage89pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.wosidWOS:000283835400011pt_BR
dc.identifier.doi10.1016/j.ejphar.2010.08.022pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-11-15T02:00:49Z
dc.date.available2015-11-26T17:35:47Z-
dc.date.accessioned2014-11-15T02:00:49Z
dc.date.accessioned2015-11-26T17:35:47Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:35:47Z (GMT). No. of bitstreams: 2 WOS000283835400011.pdf: 766316 bytes, checksum: 2e66108adf9a8dd101369abadc45038c (MD5) WOS000283835400011.pdf.txt: 35901 bytes, checksum: 380f8cf1c4fd034cb2795b0de69c2a40 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73767pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/73767
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73767-
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