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Type: Artigo de periódico
Title: Up-regulation of T lymphocyte and antibody production by inflammatory cytokines released by macrophage exposure to multi-walled carbon nanotubes
Author: Grecco, ACP
Paula, RFO
Mizutani, E
Sartorelli, JC
Milani, AM
Longhini, ALF
Oliveira, EC
Pradella, F
Silva, VDR
Moraes, AS
Peterlevitz, AC
Farias, AS
Ceragioli, HJ
Santos, LMB
Baranauskas, V
Abstract: Our data demonstrate that multi-walled carbon nanotubes (MWCNTs) are internalized by macrophages, subsequently activating them to produce interleukin (IL)-12 (IL-12). This cytokine induced the proliferative response of T lymphocytes to a nonspecific mitogen and to ovalbumin (OVA). This increase in the proliferative response was accompanied by an increase in the expression of pro-inflammatory cytokines, such as interferon-gamma (IFN gamma), tumor necrosis factor-alpha (TNF alpha) and IL-6, in mice inoculated with MWCNTs, whether or not they had been immunized with OVA. A decrease in the expression of transforming growth factor-beta (TGF beta) was observed in the mice treated with MWCNTs, whereas the suppression of the expression of both TGF beta and IL-10 was observed in mice that had been both treated and immunized. The activation of the T lymphocyte response by the pro-inflammatory cytokines leads to an increase in antibody production to OVA, suggesting the important immunostimulatory effect of carbon nanotubes.
Country: Inglaterra
Editor: Iop Publishing Ltd
Citation: Nanotechnology. Iop Publishing Ltd, v. 22, n. 26, 2011.
Rights: fechado
Identifier DOI: 10.1088/0957-4484/22/26/265103
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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