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Type: Artigo de periódico
Title: Variability and discontinuity of the pathognomonic systemic effects caused by Walker 256 tumor progression in rats
Author: Rettori, O
VieiraMatos, AN
Tahin, QS
Abstract: Cancer pathognomonic systemic effects (PSE) have high individual variability, For this reason present data were collected daily and synchronized considering four main points: inoculation day, onset of PSE, aggravation and death, The subclinical period free of PSE ranged between 15.7+/-2.2 days, the clinical period was less variable, 8.9+/-0.5 days, divided in a moderate and a grave phase of nearly the same length, PSE involved disturbances of fundamental homeostatic regulations: appetite, sodium, water, immune, etc, PSE triggering correlated highly with survival (r(2)=0.95, P<0.01), but poorly with primary tumor growth, and it was anticipated by metastases from 20.5+/-2.6 to 10.6+/-1.1 days (P<0.01), After multifocal simultaneous inoculations, PSE triggering was anticipated to 4.2+/-0.2 days (marked reduction of individual variability), in the presence of small total-tumor masses, absence of macroscopic metastases, and without changes in the following clinical period features, PSE triggering seems to be a major prognostic indicator probably related to multifocal tumor growth.
Subject: cancer pathophysiology
homeostatic disturbances
humoral effects
prognostic indication
multifocal tumor growth
Walker 256 tumor
Country: Itália
Editor: Pensiero Scientifico Editor
Citation: Tumori. Pensiero Scientifico Editor, v. 81, n. 5, n. 370, n. 377, 1995.
Rights: fechado
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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