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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleWhole cortical and default mode network mean functional connectivity as potential biomarkers for mild Alzheimer's diseasept_BR
dc.contributor.authorBalthazar, MLFpt_BR
dc.contributor.authorde Campos, BMpt_BR
dc.contributor.authorFranco, ARpt_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorCendes, Fpt_BR
unicamp.authorFigueredo Balthazar, Marcio Luiz de Campos, Brunno Machado Damasceno, Benito Pereira Cendes, Fernando Univ Estadual Campinas, Dept Neurol, UNICAMP, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorFranco, Alexandre Rosa Catholic Univ Fed Rio Grande Sul PUCRS, Brain Inst Rio Grande Sul, Porto Alegre, RS, Brazilpt_BR
dc.subjectDefault mode networkpt_BR
dc.subjectResting state fMRIpt_BR
dc.subject.wosResting-state Fmript_BR
dc.subject.wosCognitive Impairmentpt_BR
dc.description.abstractThe search for an Alzheimer's disease (AD) biomarker is one of the most relevant contemporary research topics due to the high prevalence and social costs of the disease. Functional connectivity (PC) of the default mode network (DMN) is a plausible candidate for such a biomarker. We evaluated 22 patients with mild AD and 26 age- and gender-matched healthy controls. All subjects underwent resting functional magnetic resonance imaging (fMRI) in a 3.0 T scanner. To identify the DMN, seed-based FC of the posterior cingulate was calculated. We also measured the sensitivity/specificity of the method, and verified a correlation with cognitive performance. We found a significant difference between patients with mild AD and controls in average z-scores: DMN, whole cortical positive (WCP) and absolute values. DMN individual values showed a sensitivity of 77.3% and specificity of 70%. DMN and WCP values were correlated to global cognition and episodic memory performance. We showed that individual measures of DMN connectivity could be considered a promising method to differentiate AD, even at an early phase, from normal aging. Further studies with larger numbers of participants, as well as validation of normal values, are needed for more definitive conclusions. (C) 2013 Elsevier Ireland Ltd. All rights
dc.relation.ispartofPsychiatry Research-neuroimagingpt_BR
dc.relation.ispartofabbreviationPsychiatry Res. Neuroimagingpt_BR
dc.publisherElsevier Ireland Ltdpt_BR
dc.identifier.citationPsychiatry Research-neuroimaging. Elsevier Ireland Ltd, v. 221, n. 1, n. 37, n. 42, 2014.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2011/17092-0]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T19:02:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:55:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
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