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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleThe Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells Induced by Multiwalled Carbon Nanotubes Reduces the Severity of Experimental Autoimmune Encephalomyelitispt_BR
dc.contributor.authorMoraes, ASpt_BR
dc.contributor.authorPaula, RFOpt_BR
dc.contributor.authorPradella, Fpt_BR
dc.contributor.authorSantos, MPApt_BR
dc.contributor.authorOliveira, ECpt_BR
dc.contributor.authorvon Glehn, Fpt_BR
dc.contributor.authorCamilo, DSpt_BR
dc.contributor.authorCeragioli, Hpt_BR
dc.contributor.authorPeterlevitz, Apt_BR
dc.contributor.authorBaranauskas, Vpt_BR
dc.contributor.authorVolpini, Wpt_BR
dc.contributor.authorFarias, ASpt_BR
dc.contributor.authorSantos, LMBpt_BR
unicamp.authorMoraes, Adriel S. Paula, Rosemeire F. O. Pradella, Fernando Santos, Mariana P. A. Oliveira, Elaine C. von Glehn, Felipe Camilo, Daniela S. Volpini, Walkyria Farias, Alessandro S. Santos, Leonilda M. B. Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut & Bioagents, Neuroimmunol Unit, Campinas, SP, Brazilpt_BR
unicamp.authorPradella, Fernando Santos, Mariana P. A. Farias, Alessandro S. Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut & Bioagents, Neuroimmunomodulat Grp, Campinas, SP, Brazilpt_BR
unicamp.authorCamilo, Daniela S. Ceragioli, Helder Peterlevitz, Alfredo Baranauskas, Vitor Univ Campinas UNICAMP, Campinas, SP, Brazilpt_BR
dc.subjectAntigen presentationpt_BR
dc.subjectMultiwalled carbon nanotubept_BR
dc.subject.wosT(h)17 Cellspt_BR
dc.description.abstractBackground Both Th1 and Th17 cells specific for neuroantigen are described as encephalitogenic in the experimental autoimmune encephalomyelitis (EAE) model. Aim The proposal of this study was to investigate how carbon nanotubes internalized by antigen-presenting cells (APCs) affect the development of encephalitogenic CD4(+) T cells. Methods Therefore, we stimulated encephalitogenic T cells in the presence or not of multiwalled carbon nanotube (MWCNT). After the incubation, we analyzed the expression profile of the encephalitogenic T cells and their capacity to induce EAE. Results Encephalitogenic CD4(+) T cells cultured with APCs that were previously incubated with MWCNTs do not express IL-17. The adoptive transfer of these cells causes less severe EAE than the transfer of both Th1 and Th17 cells that are not incubated with MWCNTs. These results suggest that the increased IL-27 level produced by the APCs incubated with the carbon nanotubes inhibits the development of Th17 cells. This observation is confirmed by the concomitant reduction in the level of RORt, which is a transcription factor essential for the development of Th17 cells. Moreover, the incubation of encephalitogenic T cells devoid of Th17 cells with neutralizing anti-IL-27 antibodies restored the production of IL-17. Conclusion This finding confirms the suppressive effect of IL-27 on encephalitogenic Th17 cells. The results presented suggest that the stimulation of APCs with carbon nanoparticles prior to neuroantigen presentation affects the development of the Th17 subset of encephalitogenic CD4(+) T lymphocytes and results in less severe
dc.relation.ispartofCns Neuroscience & Therapeuticspt_BR
dc.relation.ispartofabbreviationCNS Neurosci. Ther.pt_BR
dc.identifier.citationCns Neuroscience & Therapeutics. Wiley-blackwell, v. 19, n. 9, n. 682, n. 687, 2013.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsordocumentnumberFAPESP [2011/18728-5, 2012/04565-0, 2012/01408-0, 2012/09879-2, 2011/15175-5, 2011/15639-1]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T19:00:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:50:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
Appears in Collections:Unicamp - Artigos e Outros Documentos

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