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Type: Artigo de periódico
Title: Probing the mechanism of the Ugi four-component reaction with charge-tagged reagents by ESI-MS(/MS)
Author: Medeiros, GA
da Silva, WA
Bataglion, GA
Ferreira, DAC
de Oliveira, HCB
Eberlin, MN
Neto, BAD
Abstract: The mechanism of the Ugi four-component reaction has been investigated by electrospray ionization (tandem) mass spectrometry using charge-tagged reagents (a carboxylic acid or an amine) to favour detection. Key intermediates were transferred directly via ESI(+) from the reaction solution to the gas phase and characterized by MS measurements and MS/MS collision induced dissociation. The Mumm rearrangement (final step) was also investigated by both travelling wave ion mobility mass spectrometry and DFT calculations. The data seem to consolidate the amazingly selective mechanism of this intricate four-component reaction.
Country: Inglaterra
Editor: Royal Soc Chemistry
Citation: Chemical Communications. Royal Soc Chemistry, v. 50, n. 3, n. 338, n. 340, 2014.
Rights: embargo
Identifier DOI: 10.1039/c3cc47156j
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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