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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePreparation and characterisation of 5-fluorouracil containing PLGA nanospheres coated with chitosan, for drug deliverypt_BR
dc.contributor.authorCalderini, Apt_BR
dc.contributor.authorPessine, FBTpt_BR
dc.contributor.authorFranchi, GCpt_BR
dc.contributor.authorNowill, AEpt_BR
unicamp.author.emailadrianacalderini@yahoo.com.brpt_BR
unicamp.author.emailfrancisco.pessine@iqm.unicamp.brpt_BR
unicamp.author.emailgfran@unicamp.brpt_BR
unicamp.author.emailcipoi@unicamp.brpt_BR
unicamp.authorCalderini, Adriana Pessine, Francisco B. T. Univ Estadual Campinas, Inst Chem, Dept Phys Chem, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorFranchi, Gilberto C. Nowill, Alexandre E. Univ Estadual Campinas, Fac Med Sci, Oncohematol Child Res Ctr, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subject5-fluorouracilpt_BR
dc.subjectPLGApt_BR
dc.subjectChitosanpt_BR
dc.subject.wosPolymeric Nanoparticlespt_BR
dc.subject.wosIn-vivopt_BR
dc.subject.wosMicrospherespt_BR
dc.subject.wosTrehalosept_BR
dc.subject.wosReleasept_BR
dc.description.abstractThe aim of this study was to design a new Drug Delivery System (DDS) based on poly (lactide-co-glycolide) (PLGA) biodegradable nanospheres (NS) coated with Chitosan (CTS), in order to prolong its residence time and to deliver the nanoparticles more specifically to cancer cells. We have tried three methods of incorporation of Chitosan in the nanoparticles, but only one was efficient. The first method is named entanglement of chains, the second method is known as single adsorption and, in the third, we prior linked covalently Chitosan to the polymer and then prepared the nanoparticles. After selected the best method, it was monitored the stability following the temporal variation of diameter, polydispersity and zeta potential of particles prepared using different percentages of CTS and pH values, using a pre-optimised formulation of 5-fluorouracil containing PLGA NS.pt
dc.description.noteO TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE FEVEREIRO DE 2015.pt
dc.relation.ispartofInternational Journal Of Nanotechnologypt_BR
dc.relation.ispartofabbreviationInt. J. Nanotechnol.pt_BR
dc.publisher.cityGenevapt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherInderscience Enterprises Ltdpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationInternational Journal Of Nanotechnology. Inderscience Enterprises Ltd, v. 9, n. 41983, n. 851, n. 861, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber41983pt_BR
dc.description.issuespecialSIpt_BR
dc.description.firstpage851pt_BR
dc.description.lastpage861pt_BR
dc.rightsembargopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1475-7435pt_BR
dc.identifier.wosidWOS:000309703400002pt_BR
dc.identifier.doi10.1504/IJNT.2012.049450pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFAEPEX-UNICAMPpt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-07-30T18:07:53Z
dc.date.available2015-11-26T16:31:28Z-
dc.date.accessioned2014-07-30T18:07:53Z
dc.date.accessioned2015-11-26T16:31:28Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T18:07:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:31:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70083
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70083-
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