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Type: Artigo de periódico
Title: Importance of regulatory cytokine gene polymorphisms in hematopoietic stem cell transplantation
Author: Visentainer, JEL
Sell, AM
Franceschi, DA
Lieber, SR
de Souza, CA
Abstract: HLA genetic matching of donor and recipient is an important requirement for optimizing outcome following hematopoietic stein cell transplantation (HSCT). However, other non-HLA genes are being investigated,for their role in graft-versus-host disease incidence and severity and in survival, by modulating the intensity of inflammation and tissue injury. These non-HLA-encoded genes include cytokine genes with polymorphisms within the 5' or 3' regulatory sequences of the genes. The polymorphisms or microsatellites may alter the transcription factor binding sites within the gene promoters and the amount of cytokine produced This chapter summarizes the potential role of these genetic polymorphisms regarding the cytokines in predicting outcome of HSCT.
Subject: Genetic polymorphisms
Graft-versus-host disease
Hematopoietic stem cell/transplantation
Country: Brasil
Editor: Univ Sao Paulo, Conjunto Quimicas
Citation: Revista Brasileira De Ciencias Farmaceuticas. Univ Sao Paulo, Conjunto Quimicas, v. 44, n. 4, n. 739, n. 748, 2008.
Rights: aberto
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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