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Type: Artigo de periódico
Title: ORESTES are enriched in rare exon usage variants affecting the encoded proteins
Author: Sakabe, NJ
de Souza, JES
Galante, PAF
de Oliveira, PSL
Passetti, F
Brentani, H
Osorio, EC
Zaiats, AC
Leerkes, MR
Kitajima, JP
Brentani, RR
Strausberg, RL
Simpson, AJG
de Souza, SJ
Abstract: A significant fraction of the variability found in the human transcriptome is due to alternative splicing, including alternative exon usage (AEU), intron retention and use of cryptic splice sites. We present a comparison of a large-scale analysis of AEU in the human transcriptome through genome mapping of Open Reading Frame ESTs (ORESTES) and conventional ESTs. It is shown here that ORESTES probe low abundant messages more efficiently. In addition, most of the variants detected by ORESTES affect the structure of the corresponding proteins. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved.
Subject: alternative splicing
alternative exon usage
genome mapping
human transcriptome
Country: França
Editor: Elsevier France-editions Scientifiques Medicales Elsevier
Citation: Comptes Rendus Biologies. Elsevier France-editions Scientifiques Medicales Elsevier, v. 326, n. 41953, n. 979, n. 985, 2003.
Rights: fechado
Identifier DOI: 10.1016/j.crvi.2003.09.027
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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