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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleIn vitro studies of anticandidal activity of goniothalamin enantiomerspt_BR
dc.contributor.authorMartins, CVBpt_BR
dc.contributor.authorde Resende, MApt_BR
dc.contributor.authorda Silva, DLpt_BR
dc.contributor.authorMagalhaes, TFFpt_BR
dc.contributor.authorModolo, LVpt_BR
dc.contributor.authorPilli, RApt_BR
dc.contributor.authorde Fatima, Apt_BR
unicamp.author.emailadefatima@qui.ufmg.brpt_BR
unicamp.authorde Fatima, A. Univ Fed Minas Gerais, ICEx, Dept Quim, GEQOB, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
unicamp.authorMartins, C. V. B. de Resende, M. A. da Silva, D. L. Magalhaes, T. F. F. de Fatima, A. Univ Fed Minas Gerais, ICB, Dept Microbiol, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
unicamp.authorMartins, C. V. B. UNIOESTE, Ctr Engn & Ciencias Exatas, Toledo, PR, Brazilpt_BR
unicamp.authorModolo, L. V. Univ Fed Minas Gerais, ICB, Dept Bot, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
unicamp.authorPilli, R. A. Univ Estadual Campinas, IQ, Dept Quim Organ, Campinas, SP, Brazilpt_BR
dc.subjectadhesionpt_BR
dc.subjectantifungal activitypt_BR
dc.subjectbiofilmpt_BR
dc.subjectgoniothalaminpt_BR
dc.subjectnatural productspt_BR
dc.subject.wosCandida-albicans Biofilmspt_BR
dc.subject.wosEpithelial-cellspt_BR
dc.subject.wosAntifungal Activitypt_BR
dc.subject.wosCytotoxic Activitypt_BR
dc.subject.wosNatural-productspt_BR
dc.subject.wosDrug Developmentpt_BR
dc.subject.wosStyryl-lactonespt_BR
dc.subject.wosOral Candidosispt_BR
dc.subject.wosDubliniensispt_BR
dc.subject.wosFluconazolept_BR
dc.description.abstractAims: The antifungal activity of (R)-goniothalamin (1) and (S)-goniothalamin (ent-1) was evaluated against six Candida species. The in vitro effect of these compounds on yeast adhesion to human buccal epithelial cells (BEC) and Candida albicans and C. dubliniensis biofilms progression were also investigated. Methods and Results: Yeast susceptibility was evaluated by broth microdilution assay and showed that ent-1 exhibited higher potency against all fungal clinical isolated when compared to compound 1. Compounds 1 and ent-1 were as potent as fluconazole in inhibiting the adhesion of C. albicans and C. dubliniensis to BEC. XTT-reducing assay and scanning electron microscopy revealed that 1 and ent-1 were twice as potent as fluconazole in the inhibition of yeast biofilms progression. Conclusions: Our findings indicate that compounds 1 and ent-1 are potent anticandidal agents. Significance and Impact of the Study: This study highlights goniothalamin enantiomers as promising lead compounds for the design of new antifungal with inhibitory activity on yeast adhesion and biofilm progression.pt
dc.relation.ispartofJournal Of Applied Microbiologypt_BR
dc.relation.ispartofabbreviationJ. Appl. Microbiol.pt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwell Publishing, Incpt_BR
dc.date.issued2009pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationJournal Of Applied Microbiology. Wiley-blackwell Publishing, Inc, v. 107, n. 4, n. 1279, n. 1286, 2009.pt_BR
dc.language.isoenpt_BR
dc.description.volume107pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage1279pt_BR
dc.description.lastpage1286pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1364-5072pt_BR
dc.identifier.wosidWOS:000269730300024pt_BR
dc.identifier.doi10.1111/j.1365-2672.2009.04307.xpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-11-18T03:24:37Z
dc.date.available2015-11-26T16:50:23Z-
dc.date.accessioned2014-11-18T03:24:37Z
dc.date.accessioned2015-11-26T16:50:23Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:50:23Z (GMT). No. of bitstreams: 2 WOS000269730300024.pdf: 298399 bytes, checksum: dfcfa0e6640e6cd19bb4512b8defc9eb (MD5) WOS000269730300024.pdf.txt: 35750 bytes, checksum: 06722ea10a70904133303754567ba0ef (MD5) Previous issue date: 2009en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69412pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/69412
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69412-
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