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Type: Artigo de periódico
Title: IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients
Author: Lopes, MR
Traina, F
Campos, PD
Pereira, JKN
Machado-Neto, JA
Machado, HD
Gilli, SCO
Saad, STO
Favaro, P
Abstract: The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier Ltd. All rights reserved.
Subject: Myelodysplastic Syndrome
CD8(+) cells
Immune System
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Leukemia Research. Pergamon-elsevier Science Ltd, v. 37, n. 5, n. 541, n. 546, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2013.01.019
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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