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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in ratspt_BR
dc.contributor.authorPereira-da-Silva, Mpt_BR
dc.contributor.authorTorsoni, Mpt_BR
dc.contributor.authorNourani, HVpt_BR
dc.contributor.authorAugusto, VDpt_BR
dc.contributor.authorSouza, Cpt_BR
dc.contributor.authorGasparetti, ALpt_BR
dc.contributor.authorCarvalheira, Jpt_BR
dc.contributor.authorVentrucci, Gpt_BR
dc.contributor.authorMarcondes, MCCGpt_BR
dc.contributor.authorCruz-Neto, APpt_BR
dc.contributor.authorSaad, MJApt_BR
dc.contributor.authorBoschero, ACpt_BR
dc.contributor.authorCarneiro, EMpt_BR
dc.contributor.authorVelloso, Lpt_BR
unicamp.authorUniv Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Dept Physiol & Biophys, BR-13083970 Campinas, SP, Brazil State Univ Sao Paulo, Paulista State Univ, Dept Zool, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subject.wosAcid Synthase Inhibitorpt_BR
dc.subject.wosBrown Adipose-tissuept_BR
dc.subject.wosMice Lackingpt_BR
dc.subject.wosFood-intakept_BR
dc.subject.wosObese Micept_BR
dc.subject.wosGlucose-uptakept_BR
dc.subject.wosPreoptic Areapt_BR
dc.subject.wosBody-weightpt_BR
dc.subject.wosInsulinpt_BR
dc.subject.wosExpressionpt_BR
dc.description.abstractShort-term cold exposure of homeothermic animals leads to higher thermogenesis and food consumption accompanied by weight loss. An analysis of cDNA-macroarray was employed to identify candidate mRNA species that encode proteins involved in thermogenic adaptation to cold. A cDNA-macroarray analysis, confirmed by RT-PCR, immunoblot, and RIA, revealed that the hypothalamic expression of melanin-concentrating hormone (MCH) is enhanced by exposure of rats to cold environment. The blockade of hypothalamic MCH expression by antisense MCH oligonucleotide in cold-exposed rats promoted no changes in feeding behavior and body temperature. However, MCH blockade led to a significant drop in body weight, which was accompanied by decreased liver glycogen, increased relative body fat, increased absolute and relative interscapular brown adipose tissue mass, increased uncoupling protein 1 expression in brown adipose tissue, and increased consumption of lean body mass. Thus, increased hypothalamic MCH expression in rats exposed to cold may participate in the process that allows for efficient use of energy for heat production during thermogenic adaptation to cold.pt
dc.description.noteo TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.pt
dc.relation.ispartofEndocrinologypt_BR
dc.relation.ispartofabbreviationEndocrinologypt_BR
dc.publisher.cityBethesdapt_BR
dc.publisher.countryEUApt_BR
dc.publisherEndocrine Socpt_BR
dc.date.issued2003pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationEndocrinology. Endocrine Soc, v. 144, n. 11, n. 4831, n. 4840, 2003.pt_BR
dc.language.isoenpt_BR
dc.description.volume144pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage4831pt_BR
dc.description.lastpage4840pt_BR
dc.rightsembargopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESP USPpt_BR
dc.identifier.issn0013-7227pt_BR
dc.identifier.wosidWOS:000186178300025pt_BR
dc.identifier.doi10.1210/en.2003-0243pt_BR
dc.date.available2014-11-14T05:30:38Z
dc.date.available2015-11-26T16:04:43Z-
dc.date.accessioned2014-11-14T05:30:38Z
dc.date.accessioned2015-11-26T16:04:43Z-
dc.description.provenanceMade available in DSpace on 2014-11-14T05:30:38Z (GMT). No. of bitstreams: 1 WOS000186178300025.pdf: 293171 bytes, checksum: a9463cea93548babd929074d365a51e9 (MD5) Previous issue date: 2003en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:04:43Z (GMT). No. of bitstreams: 2 WOS000186178300025.pdf: 293171 bytes, checksum: a9463cea93548babd929074d365a51e9 (MD5) WOS000186178300025.pdf.txt: 55500 bytes, checksum: d696a90a563a961d7198e087b3d22f74 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69087pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/69087
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69087-
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