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Type: Artigo de periódico
Title: Fusarium infection in hematopoietic stem cell transplant recipients
Author: Nucci, M
Marr, KA
Queiroz-Telles, F
Martins, CA
Trabasso, P
Costa, S
Voltarelli, JC
Colombo, AL
Imhof, A
Pasquini, R
Maiolino, A
Souza, CA
Anaissie, E
Abstract: To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21 - 5.0 cases per 1000 in human leukocyte antigen (HLA) - matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% ( median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.
Country: EUA
Editor: Univ Chicago Press
Citation: Clinical Infectious Diseases. Univ Chicago Press, v. 38, n. 9, n. 1237, n. 1242, 2004.
Rights: fechado
Identifier DOI: 10.1086/383319
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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