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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFrequent Seizures Are Associated with a Network of Gray Matter Atrophy in Temporal Lobe Epilepsy with or without Hippocampal Sclerosispt_BR
dc.contributor.authorCoan, ACpt_BR
dc.contributor.authorCampos, BMpt_BR
dc.contributor.authorYasuda, CLpt_BR
dc.contributor.authorKubota, BYpt_BR
dc.contributor.authorBergo, FPGpt_BR
dc.contributor.authorGuerreiro, CAMpt_BR
dc.contributor.authorCendes, Fpt_BR
unicamp.author.emailfcendes@unicamp.brpt_BR
unicamp.authorCoan, Ana C. Campos, Brunno M. Yasuda, Clarissa L. Kubota, Bruno Y. Bergo, Felipe P. G. Guerreiro, Carlos A. M. Cendes, Fernando Univ Estadual Campinas, Dept Neurol, Neuroimaging Lab, Campinas, SP, Brazilpt_BR
dc.subject.wosVoxel-based Morphometrypt_BR
dc.subject.wosCortical Dysplasiapt_BR
dc.subject.wosAbnormalitiespt_BR
dc.subject.wosDurationpt_BR
dc.subject.wosMript_BR
dc.subject.wosVbmpt_BR
dc.description.abstractObjective: Patients with temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) have diffuse subtle gray matter (GM) atrophy detectable by MRI quantification analyses. However, it is not clear whether the etiology and seizure frequency are associated with this atrophy. We aimed to evaluate the occurrence of GM atrophy and the influence of seizure frequency in patients with TLE and either normal MRI (TLE-NL) or MRI signs of HS (TLE-HS). Methods: We evaluated a group of 172 consecutive patients with unilateral TLE-HS or TLE-NL as defined by hippocampal volumetry and signal quantification (122 TLE-HS and 50 TLE-NL) plus a group of 82 healthy individuals. Voxel-based morphometry was performed with VBM8/SPM8 in 3T MRIs. Patients with up to three complex partial seizures and no generalized tonic-clonic seizures in the previous year were considered to have infrequent seizures. Those who did not fulfill these criteria were considered to have frequent seizures. Results: Patients with TLE-HS had more pronounced GM atrophy, including the ipsilateral mesial temporal structures, temporal lobe, bilateral thalami and pre/post-central gyri. Patients with TLE-NL had more subtle GM atrophy, including the ipsilateral orbitofrontal cortex, bilateral thalami and pre/post-central gyri. Both TLE-HS and TLE-NL showed increased GM volume in the contralateral pons. TLE-HS patients with frequent seizures had more pronounced GM atrophy in extra-temporal regions than TLE-HS with infrequent seizures. Patients with TLE-NL and infrequent seizures had no detectable GM atrophy. In both TLE-HS and TLE-NL, the duration of epilepsy correlated with GM atrophy in extra-hippocampal regions. Conclusion: Although a diffuse network GM atrophy occurs in both TLE-HS and TLE-NL, this is strikingly more evident in TLE-HS and in patients with frequent seizures. These findings suggest that neocortical atrophy in TLE is related to the ongoing seizures and epilepsy duration, while thalamic atrophy is more probably related to the original epileptogenic process.pt
dc.relation.ispartofPlos Onept_BR
dc.relation.ispartofabbreviationPLoS Onept_BR
dc.publisher.citySan Franciscopt_BR
dc.publisher.countryEUApt_BR
dc.publisherPublic Library Sciencept_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculation46388pt_BR
dc.identifier.citationPlos One. Public Library Science, v. 9, n. 1, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber1pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.wosidWOS:000330507300026pt_BR
dc.identifier.doi10.1371/journal.pone.0085843pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFAPESP [2005/56578-4, 2009/54552-9, 2011/03477-7]pt
dc.date.available2014-07-30T17:37:10Z
dc.date.available2015-11-26T16:47:32Z-
dc.date.accessioned2014-07-30T17:37:10Z
dc.date.accessioned2015-11-26T16:47:32Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:37:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:47:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67194
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67194-
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