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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFamily-based association study for bipolar affective disorderpt_BR
dc.contributor.authorSecolin, Rpt_BR
dc.contributor.authorBanzato, CEMpt_BR
dc.contributor.authorOliveira, MCMpt_BR
dc.contributor.authorBittar, MFRpt_BR
dc.contributor.authorSantos, MLpt_BR
dc.contributor.authorDalgalarrondo, Ppt_BR
dc.contributor.authorLopes-Cendes, Ipt_BR
unicamp.author.emailicendes@unicamp.brpt_BR
unicamp.authorLopes-Cendes, Iscia Univ Estadual Campinas, FCM, Dept Med Genet, BR-13084971 Campinas, SP, Brazilpt_BR
unicamp.authorBanzato, Claudio E. M. Oliveira, Maria C. M. Dalgalarrondo, Paulo Univ Estadual Campinas, Dept Med Psychol & Psychiat, BR-13084971 Campinas, SP, Brazilpt_BR
dc.subjectgeneticspt_BR
dc.subjectmood disorderspt_BR
dc.subjectpedigree disequilibrium testpt_BR
dc.subjectsingle nucleotide polymorphismspt_BR
dc.subject.wosGenome-wide Associationpt_BR
dc.subject.wosGeneticspt_BR
dc.subject.wosGenespt_BR
dc.subject.wosSusceptibilitypt_BR
dc.subject.wosMetaanalysispt_BR
dc.subject.wosLinkagept_BR
dc.subject.wosIndividualspt_BR
dc.subject.wosDepressionpt_BR
dc.subject.wosSupportspt_BR
dc.subject.wosLocipt_BR
dc.description.abstractIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.pt
dc.relation.ispartofPsychiatric Geneticspt_BR
dc.relation.ispartofabbreviationPsychiatr. Genet.pt_BR
dc.publisher.cityPhiladelphiapt_BR
dc.publisher.countryEUApt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationPsychiatric Genetics. Lippincott Williams & Wilkins, v. 20, n. 3, n. 126, n. 129, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume20pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage126pt_BR
dc.description.lastpage129pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0955-8829pt_BR
dc.identifier.wosidWOS:000278072700008pt_BR
dc.identifier.doi10.1097/YPG.0b013e32833a2050pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [08/55827-9, 06/57332-1, 02/06831-7]pt
dc.date.available2014-11-18T21:42:22Z
dc.date.available2015-11-26T17:54:34Z-
dc.date.accessioned2014-11-18T21:42:22Z
dc.date.accessioned2015-11-26T17:54:34Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T21:42:22Z (GMT). No. of bitstreams: 1 WOS000278072700008.pdf: 89472 bytes, checksum: a638a81ca167b457d0cb1f638059b50d (MD5) Previous issue date: 2010en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:54:34Z (GMT). No. of bitstreams: 2 WOS000278072700008.pdf: 89472 bytes, checksum: a638a81ca167b457d0cb1f638059b50d (MD5) WOS000278072700008.pdf.txt: 19603 bytes, checksum: 9d664d0689ec3ef7158bcf2d025f406b (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66754pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/66754
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66754-
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