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Type: Artigo de periódico
Title: Facts, Presumptions, and Myths on the Solvent-Free and Catalyst-Free Biginelli Reaction. What is Catalysis for?
Author: Alvim, HGO
Lima, TB
de Oliveira, AL
de Oliveira, HCB
Silva, FM
Gozzo, FC
Souza, RY
da Silva, WA
Neto, BAD
Abstract: The current manuscript describes the role and importance of catalysis and solvent effects for the Biginelli multicomponent reaction. The overwhelming number of new catalysts and conditions recently published for the Biginelli synthesis, including in some manuscripts entitled "catalyst-free" and/or "solvent-free" have incentivized controversies and hot debates regarding the importance of developing new catalysts and reaction conditions to perform this very important multicomponent reaction. These so-called "catalyst-free" reports have generated much confusion in the field, requiring urgent elucidations. In this manuscript, we exemplify, demystify, and discuss the crucial role of catalysis, solvent effects, mechanisms, kinetics, facts, presumptions, and myths associated with the Biginelli reaction aiming to avoid current and future confusion and to stimulate new approaches.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Organic Chemistry. Amer Chemical Soc, v. 79, n. 8, n. 3383, n. 3397, 2014.
Rights: fechado
Identifier DOI: 10.1021/jo5001498
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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