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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleExpression of p53, c-erbB-2, Ki-67, and CD34 in granulosa cell tumor of the ovarypt_BR
dc.contributor.authorKusamura, Spt_BR
dc.contributor.authorDerchain, Spt_BR
dc.contributor.authorAlvarenga, Mpt_BR
dc.contributor.authorGomes, CPpt_BR
dc.contributor.authorSyrjanen, KJpt_BR
dc.contributor.authorAndrade, LALApt_BR
unicamp.authorUniv Estadual Campinas, Dept Obstet & Gynecol, Sch Med Sci, Campinas, Brazil Univ Estadual Campinas, Dept Pathol, Sch Med Sci, Campinas, Brazil Natl Inst Hlth, Epidemiol & Biostat Lab, Cytopathol Unit, Rome, Italypt_BR
dc.subjectbiologic markerspt_BR
dc.subjectovarian granulosa cell tumorpt_BR
dc.subject.wosMonoclonal-antibody Ki-67pt_BR
dc.subject.wosHuman Breast-cancerpt_BR
dc.subject.wosPrognostic Factorspt_BR
dc.subject.wosProliferative Activitypt_BR
dc.subject.wosSuppressor Genept_BR
dc.description.abstractThe purpose of this study is to investigate the expression of p53, c-erbB-2, Ki-67, and angiogenic activity and their correlation with the clinicopathologic characteristics in a series of granulosa cell tumors of the ovary (GCTO). Eighteen GCTO cases assisted at the Department of Obstetrics and Gynecology, School of Medical Science, UNICAMP, after diagnostic confirmation by three pathologists, were submitted to immunohistochemistry for assessment of p53, c-erbB-2, Ki-67, and CD34 expressions. The mean tumor size was 13 cm (range: 4-30 cm). Six (33%) cases presented with extraovarian disease. Thirteen (72%) cases presented some solid diffuse or sarcomatoid pattern and six (33%) moderate or strong atypia. Fourteen cases presented less than or equal to2 mitoses/10 HPF. Thirteen cases were focally positive for Ki-67. The mean Ki-67 proliferative index was 1.0%. One case presented positive expression for mutant p53 but all cases were negative for c-erbB-2 expression. The mean microvascular density was 28.9/mm(2) (range: 0-50). No significant correlations could be established between the biologic markers and clinicopathologic variables. GCTO showed a markedly low rate of immunohistochemical staining for p53 or c-erbB-2 overexpression/amplification, as well as low proliferative and angiogenic activities. Further studies are urgently needed to elaborate the factors responsible for the highly unpredictable clinical course of
dc.relation.ispartofInternational Journal Of Gynecological Cancerpt_BR
dc.relation.ispartofabbreviationInt. J. Gynecol. Cancerpt_BR
dc.publisherBlackwell Publishing Incpt_BR
dc.identifier.citationInternational Journal Of Gynecological Cancer. Blackwell Publishing Inc, v. 13, n. 4, n. 450, n. 457, 2003.pt_BR
dc.sourceWeb of Sciencept_BR
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