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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNeuroimaging predictors of AED resistance in new-onset epilepsiespt_BR
dc.contributor.authorCendes, Fpt_BR
unicamp.author.emailFcendes@unicamp.brpt_BR
unicamp.authorCendes, Fernando Univ Estadual Campinas, Dept Neurol, UNICAMP, Campinas, SP, Brazilpt_BR
dc.subjectAntiepileptic drugspt_BR
dc.subjectMagnetic resonance imagingpt_BR
dc.subjectProton MRI spectroscopypt_BR
dc.subjectOutcomept_BR
dc.subjectSeizurespt_BR
dc.subject.wosTemporal-lobe Epilepsypt_BR
dc.subject.wosSeizure Frequencypt_BR
dc.subject.wosDrug-resistancept_BR
dc.subject.wosChildhoodpt_BR
dc.subject.wosAbnormalitiespt_BR
dc.subject.wosRecurrencept_BR
dc.subject.wosRemissionpt_BR
dc.subject.wosAtrophypt_BR
dc.description.abstractThe best prognostic factors in early-onset epilepsies are the response to the first antiepileptic drug (AED) trial, age at seizure onset, number of seizures prior to treatment, and the presence of a lesion or abnormal neurologic examination. However, early and adequate response to AED is most likely an epiphenomenon reflecting the nature of underlying epileptogenicity, which may be defined as a complex interaction of underlying pathology, genetics, and environment. Patients with the same type of epileptogenic lesion, for example, hippocampal sclerosis, may have a varying response to AED. Modern neuroimaging, in particular quantitative magnetic resonance imaging (MRI) techniques may be helpful to better understand this complex interaction of factors leading to refractoriness. Patients who respond well to AEDs have no or minor MRI abnormalities, and among those with underlying lesions there is an inverse correlation between outcome and the extent of MRI-defined neuronal damage outside the main lesion, which may be undetectable by visual analyses of routine MRI. The extent of neuronal damage appears to be related to the severity of initial precipitating injuries, probably interacts with genetic factors, and may progress over time when seizures are uncontrolled. The presence and extent of abnormalities detected by quantitative MRI may also be helpful to guide AED withdrawal in those patients who are seizure free for >2 years. Combined MRI measures may have potential clinical value for predicting AED response in near future.pt
dc.relation.ispartofEpilepsiapt_BR
dc.relation.ispartofabbreviationEpilepsiapt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2011pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationEpilepsia. Wiley-blackwell, v. 52, n. 7, n. 9, 2011.pt_BR
dc.language.isoenpt_BR
dc.description.volume52pt_BR
dc.description.issuesupplement4pt_BR
dc.description.issuespecialSIpt_BR
dc.description.firstpage7pt_BR
dc.description.lastpage9pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0013-9580pt_BR
dc.identifier.wosidWOS:000292500300002pt_BR
dc.identifier.doi10.1111/j.1528-1167.2011.03143.xpt_BR
dc.date.available2014-07-30T17:23:49Z
dc.date.available2015-11-26T16:37:53Z-
dc.date.accessioned2014-07-30T17:23:49Z
dc.date.accessioned2015-11-26T16:37:53Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:23:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:37:53Z (GMT). No. of bitstreams: 2 WOS000292500300002.pdf: 44353 bytes, checksum: 9348590c9b6f405023bb4b0cc99c7166 (MD5) WOS000292500300002.pdf.txt: 13483 bytes, checksum: c742932a83d7014bbc0206d3a1a2c8f8 (MD5) Previous issue date: 2011en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65284
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65284-
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