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|Type:||Artigo de periódico|
|Title:||Effects of the Ga-As laser irradiation on myonecrosis caused by Bothrops moojeni snake venom|
da Cruz-Hofling, MA
|Abstract:||Background and Objectives: Viper snake envenoming induces in the victims systemic coagulopathy, and severe local tissue damage such as edema, hemorrhage, intense pain, and myonecrosis. Serumtherapy and other first-aid managements are ineffective in neutralizing these local effects. The effects of the gallium-arsenide (Ga-As) laser irradiation on mice gastrocnemius injected intramuscularly (i.m.) with Bothrops moojeni snake venom were investigated. Study Design/Materials and Methods: Macroscopical, histopatological, and myonecrosis quantification through serum creatine kinase (CK) evaluation was done at 3, 12, and 24 hours (two, five, and eight irradiation sessions, 4 J/cm(2), 1 minute 32 seconds per period, respectively), were done after the venom or saline injection, and in venom-unirradiated mice. Results: In unirradiated gastrocnemius, the venom induced massive hemorrhage, vascular congestion, time-progressing myonecrosis, edema, abundant inflammatory infiltrate, and high CK serum levels. Ga-As irradiation significantly decreased the amount of myonecrosis in all the periods tested (P < 0.05). Conclusions: The laser treatment significantly inhibited the ability of B. moojeni venom to rapidly disrupt the integrity of the plasma membrane. (C) 2003 Wiley-Liss, Inc.|
|Citation:||Lasers In Surgery And Medicine. Wiley-liss, v. 33, n. 5, n. 352, n. 357, 2003.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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