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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleeNOS and BDKRB2 genotypes affect the antihypertensive responses to enalaprilpt_BR
dc.contributor.authorSilva, PSpt_BR
dc.contributor.authorFontana, Vpt_BR
dc.contributor.authorLuizon, MRpt_BR
dc.contributor.authorLacchini, Rpt_BR
dc.contributor.authorSilva, WApt_BR
dc.contributor.authorBiagi, Cpt_BR
dc.contributor.authorTanus-Santos, JEpt_BR
unicamp.authorSilva, P. S. Univ Estadual Campinas, Dept Pharmacol, Campinas, SP, Brazilpt_BR
unicamp.authorFontana, V. Luizon, M. R. Lacchini, R. Tanus-Santos, J. E. Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazilpt_BR
unicamp.authorSilva, W. A., Jr. Fac Med Ribeirao Preto, Dept Genet, Ribeirao Preto, SP, Brazilpt_BR
unicamp.authorBiagi, C. Santa Casa Aracatuba, Aracatuba, SP, Brazilpt_BR
dc.subject.wosNitric-oxide Synthasept_BR
dc.subject.wosMultifactor Dimensionality Reductionpt_BR
dc.subject.wosBradykinin B2 Receptorpt_BR
dc.subject.wosDetecting Gene-genept_BR
dc.subject.wosHaplotypes Affectpt_BR
dc.subject.wosGestational Hypertensionpt_BR
dc.subject.wosErectile Dysfunctionpt_BR
dc.subject.wosT-786c Polymorphismpt_BR
dc.description.abstractThe antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is attributed partially to increased nitric oxide bioavailability. It is possible that functional polymorphisms in endothelial nitric oxide synthase (eNOS) and bradykinin receptor B2 (BDKRB2) genes may affect the antihypertensive response to enalapril. We evaluated 106 hypertensive patients treated only with enalapril for 60 days. The difference between the mean arterial pressure (MAP) before and after the antihypertensive treatment was defined as Delta MAP. If Delta MAP were below or above the median value, the patients were classified as poor responders (PR) or good responders (GR), respectively. eNOS genotypes for the T-786C, G894T and 4b/4a polymorphisms were determined and haplotype frequencies were estimated by PHASE and Haplo.stats programs. The C-58T and BE1 +9/-9 polymorphisms of BDKRB2 genes and their haplotypes were determined by DNA sequencing. Robust multifactor dimensionality reduction analysis was used to characterize gene-gene interactions. The TC/CC genotypes and the C allele for the eNOS T-786C polymorphism were more frequent in GR than in PR. Furthermore, the TT genotype for the BDKRB2 C-58T polymorphism was more frequent in PR than GR. No other significant differences in genotypes or haplotypes were found. However, we found significant gene-gene interactions: the CC genotype for the BDKRB2 C-58T polymorphism was associated with response to enalapril depending on eNOS T-786C genotypes. These findings suggest that eNOS T-786C and BDKRB2 C-58T polymorphisms may synergically affect the antihypertensive response to
dc.relation.ispartofEuropean Journal Of Clinical Pharmacologypt_BR
dc.relation.ispartofabbreviationEur. J. Clin. Pharmacol.pt_BR
dc.publisherSpringer Heidelbergpt_BR
dc.identifier.citationEuropean Journal Of Clinical Pharmacology. Springer Heidelberg, v. 69, n. 2, n. 167, n. 177, 2013.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.provenanceMade available in DSpace on 2014-07-30T17:19:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:47:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
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