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Type: Artigo de periódico
Title: Endometrial polyps in pre- and postmenopausal women: Factors associated with malignancy
Author: Antunes, A
Costa-Paiva, L
Arthuso, M
Costa, JV
Pinto-Neto, AM
Abstract: Objective: To evaluate the prevalence of premalignant and malignant polyps and their association with menopausal status, hormone therapy and clinical characteristics in perimenopausal and postmenopausal women. Methods: A surgical database was used to select pre- and postmenopausal women >= 40 years of age, submitted to hysteroscopic resection of endometrial polyps. The medical records of 475 women were reviewed and clinical characteristics and histological diagnosis of resected polyps were assessed. Results: The majority of women had benign endometriall lesions, 78.53% of which were endometrial polyps and 13.47% polyps with simple or complex endometrial hyperplasia without atypia. Polyps with endometrial hyperplasia with atypia comprised 1.05% of cases, while 2.74% were carcinomatous polyps. Analysis using prevalence ratios showed that premalignant and malignant lesions were associated with age and postmenopausal bleeding. Women > 60 years of age had a prevalence ratio 3.28 times greater (95%CI: 1.19-9.07) of premalignant or malignant polyps. When only postmenopausal women were evaluated for the effect of age, those over 60 years, of age had a prevalence 5.31 times greater (95%CI: 1.22-23.09), while those with postmenopausal bleeding had an age-adjusted prevalence ratio of 3.71 (95%CI: 1.21-11.34) compared to asymptomatic women. No significant association was found between arterial hypertension, diabetes mellitus, obesity, use of hormone therapy or tarnoxifen and premalignancy or malignancy. Conclusions: There was a low prevalence of premalignant and malignant lesions in endometrial polyps. Older women and those with postmenopausal bleeding had a greater prevalence of malignancy and in these cases hysteroscopic resection of endometrial polyps is mandatory. (c) 2007 Published by Elsevier Ireland Ltd.
Subject: menopause
anormal bleeding
risk factors
Country: Irlanda
Editor: Elsevier Ireland Ltd
Citation: Maturitas. Elsevier Ireland Ltd, v. 57, n. 4, n. 415, n. 421, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.maturitas.2007.04.010
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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