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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffectiveness of clobazam as add-on therapy in children with refractory focal epilepsypt_BR
dc.contributor.authorda Silveira, MRMpt_BR
dc.contributor.authorMontenegro, MApt_BR
dc.contributor.authorFranzon, RCpt_BR
dc.contributor.authorGuerreiro, CAMpt_BR
dc.contributor.authorGuerreiro, MMpt_BR
unicamp.author.emailmmg@fcm.unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, FCM, Dept Neurol, UNICAMP, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectclobazampt_BR
dc.subjectfocal epilepsypt_BR
dc.subjectchildhoodpt_BR
dc.subject.wosTolerancept_BR
dc.subject.wosMonotherapypt_BR
dc.subject.wosChildhoodpt_BR
dc.subject.wosEfficacypt_BR
dc.subject.wosTrialpt_BR
dc.subject.wosDrugpt_BR
dc.description.abstractThe objective of this study was to evaluate the safety and efficacy of clobazam in children with refractory focal epilepsy. We investigated 100 consecutive patients concerning etiology of epilepsy, previously used antiepileptic drugs, seizure frequency and adverse events. Clobazam was introduced as add-on therapy in patients with previous failure of at least two monotherapies. Mean age was eight years-old and 39 patients were girls. Clobazam mean dosage was 23.6 mg/day. Mean use of clobazam was 18.6 months. Twenty-two patients had adverse events. Twenty-six patients became seizure-free, 11 had an improvement of > 75% and in 58 there was no modification in seizure frequency. Five patients had an increase in seizure frequency. Clobazam efficacy lasted for more than one year in 42% of the seizure-free patients. Clobazam seems to be safe and effective in the treatment of focal epilepsy in childhood and should be considered in patients with refractory seizures.pt
dc.relation.ispartofArquivos De Neuro-psiquiatriapt_BR
dc.relation.ispartofabbreviationArq. Neuro-Psiquiatr.pt_BR
dc.publisher.citySao Paulo Sppt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAssoc Arquivos De Neuro- Psiquiatriapt_BR
dc.date.issued2006pt_BR
dc.date.monthofcirculationSEPpt_BR
dc.identifier.citationArquivos De Neuro-psiquiatria. Assoc Arquivos De Neuro- Psiquiatria, v. 64, n. 3B, n. 705, n. 710, 2006.pt_BR
dc.language.isoenpt_BR
dc.description.volume64pt_BR
dc.description.issuenumber3Bpt_BR
dc.description.firstpage705pt_BR
dc.description.lastpage710pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0004-282Xpt_BR
dc.identifier.wosidWOS:000241329500001pt_BR
dc.date.available2014-11-18T14:44:16Z
dc.date.available2015-11-26T16:55:58Z-
dc.date.accessioned2014-11-18T14:44:16Z
dc.date.accessioned2015-11-26T16:55:58Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T14:44:16Z (GMT). No. of bitstreams: 1 WOS000241329500001.pdf: 96548 bytes, checksum: a21885965ccb320a6762218b7a8e7ce9 (MD5) Previous issue date: 2006en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:55:58Z (GMT). No. of bitstreams: 2 WOS000241329500001.pdf: 96548 bytes, checksum: a21885965ccb320a6762218b7a8e7ce9 (MD5) WOS000241329500001.pdf.txt: 22157 bytes, checksum: 914e92ab1e1398dda0eb0e6631b68c0f (MD5) Previous issue date: 2006en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64034pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/64034
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64034-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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