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Type: Artigo de periódico
Title: Effect of autologous bone marrow-derived cells associated with guided bone regeneration or not in the treatment of pen-implant defects
Author: Ribeiro, FV
Suaid, FF
Ruiz, KGS
Rodrigues, TL
Carvalho, MD
Nociti, FH
Sallum, EA
Casati, MZ
Abstract: This study investigated the effect of bone marrow-derived cells associated with guided bone regeneration in the treatment of dehiscence bone defects around dental implants. Iliac-derived bone marrow cells were harvested from dogs and phenotypically characterized with regard to their osteogenic properties. After teeth extraction, three implant sites were drilled, dehiscences created and implants placed. Dehiscences were randomly assigned to: bone marrow-derived cells, bone marrow-derived cells + guided bone regeneration, and control (no treatment). After 3 months, implants with adjacent tissues were processed histologically, bone-to-implant contact, bone fill within the threads, new bone area in a zone lateral to the implant, new bone height, and new bone weight at the bottom of the defect were determined. Phenotypic characterization demonstrated that bone marrow-derived cells presented osteogenic potential. Statistically higher bone fill within the threads was observed in both bone marrow-derived cells + guided bone regeneration bone marrow-derived cell groups compared with the control group (P < 0.05), with no difference between the groups treated with cells (P > 0.05). For the other parameters (new bone area, bone-to-implant contact, new bone height and new bone weight), only the bone marrow-derived cells + guided bone regeneration group presented higher values compared with the non-treated control (P < 0.05). Bone marrow-derived cells provided promising results for peri-implantar bone regeneration, although the combined approach seems to be relevant, especially to bone formation out of the implant threads.
Subject: Dental implants
Bone regeneration
Tissue engineering
Bone marrow
Country: Escócia
Editor: Churchill Livingstone
Citation: International Journal Of Oral And Maxillofacial Surgery. Churchill Livingstone, v. 41, n. 1, n. 121, n. 127, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.ijom.2011.06.025
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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