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Type: Artigo de periódico
Title: Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides mu(1) receptor-mediated post-ictal antinociception
Author: Felippotti, TT
do Carmo, DR
Paim, LL
Stradiotto, NR
Bicalho, UD
Parada, CA
Grillo, R
Fraceto, LF
Coimbra, NC
Abstract: The aim of this study was to investigate the capacity of the host dendrimer DAB-Am-16 as a drug carrier to reduce the time required for the encapsulated naloxonaxine to establish an irreversible covalent bond with mu(1)-opioid receptor (resulting in a pharmacologically selective effect). The efficacy of dendrimer-naloxonazine nanocomplex (DNC) was studied in antinociception induced by convulsions elicited by intraperitoneal (IP) administration of pentylenetetrazole, and analgesia was measured by the tail-flick test. We found that animals showed increased tail-flick latencies following convulsions. Furthermore, acute pre-treatment (10 minutes) with DNC, but not with naloxonazine alone, antagonized post-ictal analgesia in comparison with control pre-treatment. However, naloxonazine treatment 24 hours before PTZ decreased post-ictal antinociception, but DNC failed to antagonize tonic-clonic seizure-induced analgesia. In addition, according to Racine's index of seizure severity, naloxonazine, DAB-Am-16 dendrimer or DNC did not influence seizure severity when administered either 10 minutes or 24 hours before PTZ. From the Clinical Editor: This study characterizes the effect of a dendrimer-naloxonazine complex on mu(1) receptor-mediated post-ictal antinociception in an animal model of seizure disorder. (C) 2011 Elsevier Inc. All rights reserved.
Subject: DAB-Am-16 Dendrimer
GABA-A receptor
mu(1)-opioid receptor
Post-ictal analgesia
nanostructured materials
Country: Holanda
Editor: Elsevier Science Bv
Citation: Nanomedicine-nanotechnology Biology And Medicine. Elsevier Science Bv, v. 7, n. 6, n. 871, n. 880, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.nano.2011.02.005
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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