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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNeck circumference as a simple tool for identifying the metabolic syndrome and insulin resistance: results from the Brazilian Metabolic Syndrome Studypt_BR
dc.contributor.authorStabe, Cpt_BR
dc.contributor.authorVasques, ACJpt_BR
dc.contributor.authorLima, MMOpt_BR
dc.contributor.authorTambascia, MApt_BR
dc.contributor.authorPareja, JCpt_BR
dc.contributor.authorYamanaka, Apt_BR
dc.contributor.authorGeloneze, Bpt_BR
unicamp.authorStabe, Christiane Junqueira Vasques, Ana Carolina Oliveira Lima, Marcelo Miranda Tambascia, Marcos Antonio Geloneze, Bruno State Univ Campinas UNICAMP, Dept Clin Med, Lab Res Metab & Diabet, Sao Paulo, Brazilpt_BR
unicamp.authorPareja, Jose Carlos State Univ Campinas UNICAMP, Dept Surg, Lab Res Metab & Diabet, Sao Paulo, Brazilpt_BR
unicamp.authorYamanaka, Ademar State Univ Campinas UNICAMP, Dept Clin Med, Sao Paulo, Brazilpt_BR
dc.subject.wosVisceral Adipose-tissuept_BR
dc.subject.wosWaist Circumferencept_BR
dc.subject.wosCardiometabolic Riskpt_BR
dc.subject.wosScientific Statementpt_BR
dc.subject.wosConsensus Statementpt_BR
dc.subject.wosAbdominal Fatpt_BR
dc.description.abstractObjective To investigate the relationship of the neck circumference (NC) with the metabolic syndrome (MetS) and insulin resistance (IR) in a large Brazilian population-based sample, within a wide range of adiposity and glucose tolerance, and to establish cut-off values of the NC for MetS and IR. Context The NC correlates with cardiovascular risk factors, IR and components of MetS. Upper-body subcutaneous (sc) fat, as estimated by the NC, is associated with cardiovascular risk factors as much as abdominal fat, which is usually estimated by the waist circumference (WC). There are few epidemiological population-based studies on the clinical significance of the NC to MetS and IR. Design This is a cross-sectional study. Patients About 1053 Brazilian adults (1860years). Measurements Patients with BMI 18 center dot 540 center dot 0kg/m2, with normal glucose tolerance or type 2 diabetes (T2DM), were submitted to anthropometric measurements including waist circumference (WC), NC and BMI. Abdominal visceral fat (VF) was assessed by ultrasound. Insulin sensitivity (IS) was assessed by euglycaemichyperinsulinaemic clamp (10% of total sample) and HOMA-IR. Spearman correlations were used to evaluate the association between NC and IR and MetS risk factors. Receiver operating characteristic (ROC) curves were used for gender-specific cut-off values for the prediction of IR and MetS. Binary logistic regression analysis was used to assess the chance of developing IR or MetS according to the enlargement of NC and WC. Results The sample consisted of 28 center dot 6% men, with a mean age of 39 center dot 4 (12years). T2DM diagnosis was present in 306 individuals, of whom 34% were men. NC correlated with WC and BMI in both men and women (P<0 center dot 001). In both genders, NC showed a positive correlation with triglycerides, fasting glucose, fasting insulin and HOMA-IR, and NC had a negative association with high-density lipoprotein (HDL). NC and IS showed a moderate negative correlation. A significant correlation was demonstrated between VF and NC. In the ROC curves, NC presented the largest AUC for IR in women (P<0 center dot 001), while NC presented a large AUC for MetS in both genders. Conclusions Neck circumference measurements are an alternative and innovative approach for determining body fat distribution. The NC is positively associated with MetS risk factors, IR and VF, with established cut-off values for the prediction of MetS and
dc.relation.ispartofClinical Endocrinologypt_BR
dc.relation.ispartofabbreviationClin. Endocrinol.pt_BR
dc.identifier.citationClinical Endocrinology. Wiley-blackwell, v. 78, n. 6, n. 874, n. 881, 2013.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [2007/58638-0]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T17:04:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:45:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
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