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Type: Artigo de periódico
Title: Characterisation of a new splice variant of MASK-BP3(ARF) and MASK human genes, and their expression patterns during haematopoietic cell differentiation
Author: Duarte, ADS
Traina, F
Favaro, PMB
Basseres, DS
de Carvalho, IC
Medina, SD
Costa, FF
Saad, STO
Abstract: In this study we report the characterisation of a new splice variant, here denominated splice variant 4 (accession number AF258557) of the human Multiple Ankyrin repeats Single KH domain (hMASK) (accession number AF521882) and the hMASK-4E-Binding Protein 3 Alternative Reading Frame (hMASK-BP3(ARF)) (accession number AF521883), containing a number of ANK-repeat motifs. Ankyrin (ANK) repeat-containing proteins carry out a wide variety of biological activities and are involved in processes, such as cell differentiation and transcriptional regulation. The present study reports the computer analysis of these splice variant cDNAs and their broad mRNA expression in different normal human tissues and cancer cell lines. An upregulation of the splice variant mRNAs expression was observed after HL-60 and erythroblast differentiation. The upregulation of splice variant 4 mRNA was considerably higher than those of the other variants, during erythroid differentiation. (c) 2005 Elsevier B.V. All rights reserved.
Subject: ankyrin repeat domain
alternative splicing
haernatopoietic cell differentiation
Country: Holanda
Editor: Elsevier Science Bv
Citation: Gene. Elsevier Science Bv, v. 363, n. 113, n. 122, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.gene.2005.08.002
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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