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Type: Artigo de periódico
Title: Cerebral hemometabolism: variability the acute phase of traumatic coma
Author: Falcao, ALE
Araujo, S
Dragosavac, D
Terzi, RGG
Thiesen, RAS
Cintra, EA
Sardinha, LAC
Neto, AC
Dantas, VP
Quagliato, EMAB
Abstract: Objective: to evaluate the interrelationships between cerebral and systemic hemometabolic alterations in patients with severe traumatic brain injury managed according to a standardized therapeutic protocol. Design: prospective, interventional study in patients with traumatic coma. Setting: a general Intensive Care Unit in a teaching hospital. Patients and methods: twenty-seven patients (21M e 6F), aging 14-58 years, with severe acute brain trauma, presenting with three to eight points on the Glasgow Coma Scale, were prospectively evaluated according to a cumulative protocol for the management of acute intracranial hypertension, where intracranial pressure (ICP) and cerebral extraction of oxygen (CEO3) were routinely measured. Hemometabolic interrelationships involving mean arterial pressure (MAP), ICP, arterial carbon dioxide tension (PaCO2), CEO2, cerebral perfusion pressure (CPP) and systemic extraction of oxygen (SEO2) were analyzed. Interventions: routine therapeutic procedures. Results. no correlation was found between CEO2 and CPP (r = -0.07; p = 0.41). There was a significant negative correlation between PaCO2 and CEO2 (r = -0.24; p = 0.005) and a positive correlation between SEO2 and CEO2 (r = 0.24; p = 0 01). The mortality rate in this group of patients was 25.9% (7/27). Conclusion: 1) CPP and CEO2 are unrelated; 2) CEO2 and PaCO2 ore closely related; 3) during optimized hyperventilation, CEO2 and SEO2 are coupled.
Subject: traumatic brain injury
cerebral extraction of oxygen
intracranial pressure
cerebral perfusion pressure
cerebral blood flow
Country: Brasil
Editor: Assoc Arquivos De Neuro- Psiquiatria
Citation: Arquivos De Neuro-psiquiatria. Assoc Arquivos De Neuro- Psiquiatria, v. 58, n. 3B, n. 877, n. 882, 2000.
Rights: aberto
Identifier DOI: 10.1590/S0004-282X2000000500013
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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