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Type: Artigo de periódico
Title: Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord
Author: Tambeli, CH
Levine, JD
Gear, RW
Abstract: The duration of noxious stimulus-induced antinociception (NSIA) has been shown to outlast the pain stimulus that elicited it, however, the mechanism that determines the duration of analgesia is unknown. We evaluated the role of spinal excitatory and inhibitory receptors (NMDA, mGluR(5), mu-opioid, GABA(A), and GABA(B)), previously implicated in NSIA initiation, in its maintenance. As in our previous studies, the supraspinal trigeminal jaw-opening reflex (JOR) in the rat was used for nociceptive testing because of its remoteness from the region of drug application, the lumbar spinal cord. NSIA was reversed by antagonists for two inhibitory receptors (GABA(B) and mu-opioid) but not by antagonists for either of the two excitatory receptors (NMDA and mGluR(5)), indicating that NSIA is maintained by ongoing activity at inhibitory synapses in the spinal cord. Furthermore, spinal administration of the GABAB agonist baclofen mimicked NSIA in that it could be blocked by prior injection of the p-opioid receptor antagonist H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH(2) (CTAP) in nucleus accumbens. CTAP also blocked baclofen antinociception when administered in the spinal cord. We conclude that analgesia induced by noxious stimulation is maintained by activity in spinal inhibitory receptors. (C) 2009 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
Subject: Pain-induced analgesia
Nucleus accumbens
Spinal cord
Country: Holanda
Editor: Elsevier Science Bv
Citation: Pain. Elsevier Science Bv, v. 143, n. 3, n. 228, n. 232, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.pain.2009.03.005
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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