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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDoes the Type of Prostatic Atrophy Influence the Association of Extent of Atrophy in Needle Biopsies and Serum Prostate-specific Antigen Levels?pt_BR
dc.contributor.authorBillis, Apt_BR
dc.contributor.authorMeirelles, Lpt_BR
dc.contributor.authorFreitas, LLLpt_BR
dc.contributor.authorMagna, LApt_BR
dc.contributor.authorFerreira, Upt_BR
unicamp.authorUniv Estadual Campinas, Dept Pathol Genet & Biostat, Sch Med, Sao Paulo, Brazil Univ Estadual Campinas, Dept Urol, Sch Med, Sao Paulo, Brazilpt_BR
dc.subject.wosProliferative Inflammatory Atrophypt_BR
dc.subject.wosPostatrophic Hyperplasiapt_BR
dc.description.abstractOBJECTIVES To consider the possibility that a positive and significant association between extent of atrophy and serum total or free prostate-specific antigen (PSA) elevation in patients with biopsies showing no cancer, high-grade prostatic intra-epithelial neoplasia or areas suspicious for cancer found in a previous study may be related to the type of atrophy. METHODS The only diagnosis in 75 extended biopsies was focal prostatic atrophy. Both partial and complete atrophy were considered. Complete atrophy was subtyped into simple, hyperplastic, and sclerotic atrophy. The extent of each type of atrophy was Measured in 2 ways: the linear extent in millimeters and the percentage of linear extent showing atrophy for each biopsy. On the basis of the median value of serum total PSA, the patients were divided into 2 groups: group A patients with PSA <= 8.2 ng/mL, and group B patients with PSA > 8.2 ng/mL. RESULTS There was a positive and statistically significant correlation of the linear atrophy extent as well as the percentage of linear extent with total and free serum PSA level. There was no statistically significant difference in the distribution of extent according to the type of atrophy between groups A and B. CONCLUSIONS There is a positive and significant association between extent of atrophy and serum PSA elevation. This association is not related to the type of atrophy. We hypothesize that stress-induced response by inflammation and/or ischemia may interfere in the physiological barrier that prevents any significant amount of PSA to gain the general circulation. UROLOGY 74: 1111-1115, 2009. (C) 2009 Elsevier
dc.publisher.cityNew Yorkpt_BR
dc.publisherElsevier Science Incpt_BR
dc.identifier.citationUrology. Elsevier Science Inc, v. 74, n. 5, n. 1111, n. 1115, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
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