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Type: Artigo de periódico
Title: Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation
Author: Dreyfuss, JL
Veiga, SS
Coulson-Thomas, VJ
Santos, IA
Toma, L
Coletta, RD
Nader, HB
Abstract: Glycosaminoglycans (GAGs) play important roles in cell behavior and have the ability to bind and modulate cytokines. Using primary cultured fibroblasts from hereditary gingival fibromatosis (HGF), normal gingiva (NG), and NG treated with cyclosporin-A (NGc) we show changes in the expression and structural characteristics of GAGs as well as in the expression of enzymes involved in their biosynthesis and degradation. In addition, we show the over-expression of TGF-beta 1 and TGF-beta type 11 receptor in HGF and NGc. There is an increase in the GAGs retained in the cellular fraction, and the fine structure of galactosaminoglycans show a decrease in alpha-L-iduronic acid content in HGF and NGc. Elevated extracellular levels of low molecular weight hyaluronan (HA) are found in HGF due to increase in the expression of HA synthase 3 and hyaluronidases 1 and 2. The results bring new insights to the accumulation of extracellular matrix related to TGF-beta over-expression.
Subject: Sulfated glycosaminoglycans
growth factors
hyaluronan synthases
Country: Inglaterra
Editor: Informa Healthcare
Citation: Growth Factors. Informa Healthcare, v. 28, n. 1, n. 24, n. 33, 2010.
Rights: fechado
Identifier DOI: 10.3109/08977190903321819
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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