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Type: Artigo de periódico
Title: Differences in human antioxidized LDL autoantibodies in patients with stable and unstable angina
Author: Fernandes, JL
Orford, JL
Garcia, C
Coelho, OR
Gidlund, M
Blotta, MHSL
Abstract: Background: Autoantibodies to oxidized LDL (anti-oxLDL) have been found in the serum of patients with coronary artery disease (CAD). This study was designed to compare the differences in anti-oxLDL titers and isotypes in unstable and stable angina patients and to correlate these results with known markers of active inflammation in CAD. Methods: Thirty patients from a tertiary referral general hospital with documented CAD were studied. Anti-oxLDL IgG titers and its isotypes, high sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) were measured. Results: The anti-oxLDL IgG titer was lower (p = 0.03) in the unstable angina group compared to the stable angina patients (0.084 +/- 0.102 OD versus 0.195 +/- 0.149 OD, respectively). The predominant IgG isotype in both groups was IgG2. IgG4 was significantly higher (0.270 +/- 0.146 OD, p = 0.04) in the unstable angina group versus patients with stable angina (0.198 +/- 0.019 OD). There was a significant inverse correlation between anti-oxLDL and hsCRP and SAA in this sample population (R 0.37, p < 0.05 and R = 0.36, p < 0.05, respectively). Conclusion: Patients with unstable angina have lower levels of anti-oxLDL IgG in the acute setting of CAD. Plaque instabilization does not seem to acutely modify the isotype subsets of anti-oxLDL IgG in these patients. (C) 2004 Elsevier Ltd. All rights reserved.
Subject: atherosclerosis
coronary artery disease
immune system
Country: Inglaterra
Editor: Academic Press Ltd Elsevier Science Ltd
Citation: Journal Of Autoimmunity. Academic Press Ltd Elsevier Science Ltd, v. 23, n. 4, n. 345, n. 352, 2004.
Rights: fechado
Identifier DOI: 10.1016/j.jaut.2004.08.004
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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