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Type: Artigo de periódico
Title: Diagnosis and follow-up of keratoacanthoma-like lesions: Clinical-histologic study of 43 cases
Author: Magalhaes, RF
Cruvinel, GT
Cintra, GF
Cintra, ML
Ismael, APPB
De Moraes, AM
Abstract: Background. Keratoacanthorna (KA) is easily confused with squamous cell carcinoma (SCC) on a clinical or a histopathologic basis. However, KA undergoes spontaneous regression, whereas SCC does not. Objective: Our objective was to study the histopathologic features associated with clinical regression in KA-like lesions to support the therapeutic option. Methods: Forty-three biopsies of KA-like lesions were taken at patient admission. One month later, surgical excision was performed in 18 growing lesions. Regressing lesions were left untreated. Classic histopathologic features and diagnosis were blindly recorded in both biopsies and surgical specimens. Results: On a clinical and a histologic basis, 32 lesions were assessed as KA and 11 as SCC. Features that indicated malignancy were observed in both groups, but the probability of SCC was 31 times higher in tumors with five or more of such features. Several of the histologically atypical lesions were found to regress. Conclusion: SCCs and KAs have more pathologic similarities than differences, especially in the proliferative phase. The combination of the most useful features did not allow the nosologic diagnosis in difficult cases but helped. Differential diagnosis was easier to determine after the 1-month follow up. Complete surgical excision should be indicated in nonregressing and growing lesions.
Country: Canadá
Editor: B C Decker Inc
Citation: Journal Of Cutaneous Medicine And Surgery. B C Decker Inc, v. 12, n. 4, n. 163, n. 173, 2008.
Rights: fechado
Identifier DOI: 10.2310/7750.2008.07042
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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