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Type: Artigo de periódico
Title: Development of a sensor for L-Dopa based on Co(DMG)(2)ClPy/multi-walled carbon nanotubes composite immobilized on basal plane pyrolytic graphite electrode
Author: Leite, FRF
Maroneze, CM
de Oliveira, AB
dos Santos, WTP
Damos, FS
Luz, RDS
Abstract: L-Dopa is the immediate precursor of the neurotransmitter dopamine, being the most widely prescribed drug in the treatment of Parkinson's disease. A sensitive and selective method is presented for the voltammetric determination of L-Dopa in pharmaceutical formulations using a basal plane pyrolytic graphite (BPPG) electrode modified with chloro(pyridine)bis(dimethylglyoximato)cobalt(III) (Co(DMG)(2)ClPy) absorbed in a multi-walled carbon nanotube (MWCNT). Scanning Electron Microscopy and Fourier Transform Infrared Spectroscopy were used to characterize the materials. The electrocatalytical oxidation of L-Dopa using the Co(DMG)(2)ClPy/MWCNT/BPPG electrode was investigated by cyclic voltammetry and square wave voltammetry. The parameters that influence the electrode response (the amount of Co(DMG)(2)ClPy and of MWCNT, buffer solution, buffer concentration, buffer pH, frequency and potential pulse amplitude) were investigated. Voltammetric peak currents showed a linear response for L-Dopa concentration in the range of 3 to 100 mu M, with a sensitivity of 4.43 mu Acm(-2)/mu M and a detection limit of 0.86 mu M. The related standard deviation for 10 determinations of 50 mu M L-Dopa was 1.6%. The results obtained for L-Dopa determination in pharmaceutical formulations (tablets) were in agreement with the compared official method. The sensor was successfully applied for L-Dopa selective determination in pharmaceutical formulations. (C) 2012 Elsevier B.V. All rights reserved.
Subject: L-Dopa oxidation
Chloro(pyridine)bis(dimethylglyoximato) cobalt(III)
Multi-walled carbon nanotube
Basal plane pyrolytic graphite
Country: Suíça
Editor: Elsevier Science Sa
Citation: Bioelectrochemistry. Elsevier Science Sa, v. 86, n. 22, n. 29, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.bioelechem.2012.01.001
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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