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Type: Artigo de periódico
Title: Interleukin-8 Gene Promoter Polymorphism (rs4073) May Contribute to Chronic Periodontitis
Author: Andia, DC
de Oliveira, NFP
Letra, AM
Nociti, FH
Line, SRP
de Souza, AP
Abstract: Background: The proinflammatory chemokine interleukin (IL)-8 is important in the regulation of the inflammatory response. Analyses of the single nucleotide polymorphism (SNP) reference sequence (rs) 4073 showed that the A allele upregulated IL-8 levels after stimulation with lipopolysaccharides. We investigated the association of the SNP rs4073 with chronic periodontitis. Methods: Genotyping was performed by a standard polymerase chain reaction restriction fragment length polymorphism assay in 289 genomic DNA samples of healthy control subjects and patients with chronic periodontitis; analyses were adjusted by multivariate logistic regression modeling. A real-time polymerase chain reaction performance was used to detect levels of the IL-8 mRNA. Results: The analysis pointed to a statistically significant association of chronic periodontitis with the heterozygous TA genotype (P = 0.001); the results showed an increase in the frequency of the A allele in the diseased group (36% in the control group versus 48% in the periodontitis group). The higher levels of the IL-8 mRNA were found in the periodontitis group, mainly in individuals who presented the TA genotype (P = 0.03). Conclusion: The SNP rs4073 was associated with chronic periodontitis in non-smoker Brazilian subjects because the frequency of the A allele was higher in the disease group than in the control group, and the TA genotype was associated with increased levels of IL-8 mRNA transcripts. J Periodontol 2011;82:893-899.
Subject: Alleles
polymorphism, single nucleotide
Country: EUA
Editor: Amer Acad Periodontology
Citation: Journal Of Periodontology. Amer Acad Periodontology, v. 82, n. 6, n. 893, n. 899, 2011.
Rights: fechado
Identifier DOI: 10.1902/jop.2010.100513
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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