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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInterferential therapy produces antinociception during application in various models of inflammatory painpt_BR
dc.contributor.authorJorge, Spt_BR
dc.contributor.authorParada, CApt_BR
dc.contributor.authorFerreira, SHpt_BR
dc.contributor.authorTambeli, CHpt_BR
unicamp.authorUniv Estadual Campinas, Fac Dent, Dept Physiol, Sao Paulo, Brazil Univ Sao Paulo, Fac Med, Dept Pharmacol, Sao Paulo, Brazilpt_BR
dc.subjectinflammatory painpt_BR
dc.subjectinterferential therapypt_BR
dc.subject.wosElectrical Nerve-stimulationpt_BR
dc.subject.wosDifferentiated Hl-60 Cellspt_BR
dc.subject.wosInduced Ischemic Painpt_BR
dc.subject.wosAspirin-like Drugspt_BR
dc.subject.wosFormalin Testpt_BR
dc.subject.wosNociceptor Sensitizationpt_BR
dc.subject.wosSubcutaneous Formalinpt_BR
dc.subject.wosReceptor Antagonistpt_BR
dc.subject.wosOpioid Receptorspt_BR
dc.description.abstractBackground and Purpose. Although interferential therapy (IFT) is used widely in the management of many painful conditions, the effectiveness and the mechanism of action of IFT in animal models of inflammatory pain have not been evaluated. The aim of this study was to evaluate the effectiveness of IFT in reducing inflammatory pain and edema in rats. Subjects. Sixty-nine male Wistar rats were used in the study. Methods. The effect of IFT application (4,000-Hz carrier frequency, 140-Hz amplitude-modulated beat frequency, pulse duration=125 milliseconds, current intensity=5 mA) for 1 hour on the formalin-induced nociceptive response and edema. and on carrageenan-induced mechanical hyperalgesia and edema was evaluated. Results. Interferential therapy significantly reduced the formalin-evoked nociceptive response when applied to the paw immediately after but not before the formalin, injection. Interferential therapy application at 2 hours after the carrageenan injection significantly prevented a further increase in carrageenan-induced mechanical hyperalgesia only immediately after discontinuation of the electrical current application. The antinociception induced by IFT was not attributable to a reduction in inflammation because IFT did not significantly reduce the edema induced by either formalin or carrageenan. Discussion and Conclusion. The results suggest that, despite its short-duration effect, IFT is effective in reducing inflammatory pain and should be considered primarily for use in the control of acute inflammatory
dc.relation.ispartofPhysical Therapypt_BR
dc.relation.ispartofabbreviationPhys. Ther.pt_BR
dc.publisherAmer Physical Therapy Assocpt_BR
dc.identifier.citationPhysical Therapy. Amer Physical Therapy Assoc, v. 86, n. 6, n. 800, n. 808, 2006.pt_BR
dc.sourceWeb of Sciencept_BR
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